Rapid insulinotropic action of low doses of Bisphenol-A on mouse and human islets of Langerhans: Role of estrogen receptor β

Sergi Soriano, Paloma Alonso-Magdalena, Marta García-Arévalo, Anna Novials, Sarheed J. Muhammed, Albert Salehi, Jan Ake Gustafsson, Ivan Quesada, Angel Nadal

Research output: Contribution to journalArticle

123 Scopus citations

Abstract

Bisphenol-A (BPA) is a widespread endocrine-disrupting chemical (EDC) used as the base compound in the manufacture of polycarbonate plastics. It alters pancreatic β-cell function and can be considered a risk factor for type 2 diabetes in rodents. Here we used ERβ-/- mice to study whether ERβ is involved in the rapid regulation of K ATP channel activity, calcium signals and insulin release elicited by environmentally relevant doses of BPA (1 nM). We also investigated these effects of BPA in β-cells and whole islets of Langerhans from humans. 1 nM BPA rapidly decreased K ATP channel activity, increased glucose-induced [Ca 2+] i signals and insulin release in β-cells from WT mice but not in cells from ERβ-/- mice. The rapid reduction in the K ATP channel activity and the insulinotropic effect was seen in human cells and islets. BPA actions were stronger in human islets compared to mouse islets when the same BPA concentration was used. Our findings suggest that BPA behaves as a strong estrogen via nuclear ERβ and indicate that results obtained with BPA in mouse β-cells may be extrapolated to humans. This supports that BPA should be considered as a risk factor for metabolic disorders in humans.

Original languageEnglish (US)
Article numbere31109
JournalPLoS ONE
Volume7
Issue number2
DOIs
StatePublished - Feb 8 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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