Abstract
Sepsis is a leading cause of death. Rapid and accurate identification of pathogens and antimicrobial resistance directly from blood culture could improve patient outcomes. The FilmArray® (FA; Idaho Technology, Salt Lake City, UT, USA) Blood Culture (BC) panel can identify >25 pathogens and 4 antibiotic resistance genes from positive blood cultures in 1 h. We compared a development version of the panel to conventional culture and susceptibility testing on 102 archived blood cultures from adults and children with bacteremia. Of 109 pathogens identified by culture, 95% were identified by FA. Among 111 prospectively collected blood cultures, the FA identified 84 (91%) of 92 pathogens covered by the panel. Among 25 Staphylococcus aureus and 21 Enterococcus species detected, FA identified all culture-proven methicillin-resistant S. aureus and vancomycin-resistant enterococci. The FA BC panel is an accurate method for the rapid identification of pathogens and resistance genes from blood culture.
Original language | English (US) |
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Pages (from-to) | 349-355 |
Number of pages | 7 |
Journal | Diagnostic Microbiology and Infectious Disease |
Volume | 74 |
Issue number | 4 |
DOIs | |
State | Published - Dec 2012 |
Keywords
- Bacteremia
- Blood culture
- Bloodstream infection
- FilmArray
- Molecular diagnostics
- Polymerase chain reaction
- Sepsis
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases