Rapid determination of fibrinogen by thrombokinetics

Ethan Natelson; D. F. Dooley

doi:10.1093/ajcp/61.6.828

Rapid determination of fibrinogen by thrombokinetics

Ethan Natelson, D. F. Dooley

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

The authors demonstrate that under specific conditions the maximal rate of change in optical density (VmaxΔOD) of plasma resulting from addition of thrombin with subsequent conversion of fibrinogen to fibrin is directly related to the concentration of clottable fibrinogen. Plasma fibrinogen concentration determined in seconds by this thrombokinetic analysis correlates significantly (r> 0.95, p<0.001) with fibrinogen quantitation measured by desiccated clot weight and by biuret digestion of a thrombin induced fibrin clot.

Original language	English (US)
Pages (from-to)	828-833
Number of pages	6
Journal	American Journal of Clinical Pathology
Volume	61
Issue number	6
DOIs	https://doi.org/10.1093/ajcp/61.6.828
State	Published - Jan 1 1974

ASJC Scopus subject areas

Pathology and Forensic Medicine

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AB - The authors demonstrate that under specific conditions the maximal rate of change in optical density (VmaxΔOD) of plasma resulting from addition of thrombin with subsequent conversion of fibrinogen to fibrin is directly related to the concentration of clottable fibrinogen. Plasma fibrinogen concentration determined in seconds by this thrombokinetic analysis correlates significantly (r> 0.95, p<0.001) with fibrinogen quantitation measured by desiccated clot weight and by biuret digestion of a thrombin induced fibrin clot.

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Rapid determination of fibrinogen by thrombokinetics

Abstract

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