Rapid determination of fibrinogen by thrombokinetics

Ethan Natelson, D. F. Dooley

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The authors demonstrate that under specific conditions the maximal rate of change in optical density (VmaxΔOD) of plasma resulting from addition of thrombin with subsequent conversion of fibrinogen to fibrin is directly related to the concentration of clottable fibrinogen. Plasma fibrinogen concentration determined in seconds by this thrombokinetic analysis correlates significantly (r> 0.95, p<0.001) with fibrinogen quantitation measured by desiccated clot weight and by biuret digestion of a thrombin induced fibrin clot.

Original languageEnglish (US)
Pages (from-to)828-833
Number of pages6
JournalAmerican Journal of Clinical Pathology
Issue number6
StatePublished - Jan 1 1974

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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