Abstract

OBJECTIVE:: To review an institutional experience with radiotherapy (RT) in patients with metastatic Ewing sarcoma. METHODS:: Thirty patients with metastatic Ewing sarcoma were considered. Twenty-nine received multiagent chemotherapy, whereas 22 had local therapy, which included RT in 14, surgery in 5, and surgery followed by RT in 3. RESULTS:: The 5-year overall survival rate was 22.1%. On multivariate analysis, presence of uncommon sites of metastasis (brain, liver, spleen) (P<0.0001) and use of local therapy to the primary site (P<0.001) were adverse factors for survival. Local control was not achieved in the 8 patients receiving only chemotherapy. All long-term survivors had local therapy including RT to metastatic bony sites and whole-lung irradiation for pulmonary metastasis. CONCLUSIONS:: The presence of uncommon sites of metastasis confers a worse prognosis. Aggressive primary treatment including RT to metastatic sites should be considered in these patients.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume36
Issue number3
DOIs
StatePublished - Jun 2013

Keywords

  • Ewing sarcoma
  • metastasis
  • prognosis
  • radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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