Radiotherapy Combined with Daily Administration of Low Dose Cisplatin for Head and Neck Cancer — Studies on Serum Concentrations of Cisplatin and Acute Complications —

Masahiro Fujita, Norie Masaki, Shigeyuki Murayama, Yoshinobu Matayoshi, Hiroshi Ikeda, Kimishige Shimizutani, Toshihiko Inoue, Takahiro Kozuka

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Serum concentrations of cisplatin (CDDP) and acute complications were studied in patients treated for head and neck cancer by radiotherapy combined with daily administration of low doses of CDDP (5 mg/m2 or 6 mg/body) at Osaka University Hospital between March 1988 and December 1989. Serum concentrations of total-CDDP (6 patients) and free-CDDP (2 patients) were studied in cases injected intravenously with 5 mg/m2 daily. Total-CDDP determined just before daily administration of CDDP was increased gradually (0.35 to 0.64 μg/ml by the 7th day, 0.42 to 0.91 μg/ml by the 14th day and 0.60 to 0.82 μg/m/ by the 20 or 21st day) and still observed in the serum for more than two weeks after cessation of the chemotherapy. Serum concentrations of free-CDDP were about 0.35 μg/ml at 5 minutes and 0.15 μg/ml at 30 minutes after the intravenous injection of CDDP. Incidence of the acute complications more severe than grade 2 were nausea and vomiting: 4/52 (8%), leukopenia: 11/52 (21%) and thrombocytopenia: 4/52 (8%), Incidence of myelosuppression (leukopenia and/or thrombocytopenia) was 11/26 (42%) when the total dose of CDDP exceeded 120 mg, and 3/26 (12%) when it was less than 120 mg. Transient renal dysfunction (increase of serum creatinine) of grade 1 was seen in only 3 patients.

Original languageEnglish (US)
Pages (from-to)255-262
Number of pages8
JournalThe Journal of JASTRO
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1990

Keywords

  • Acute complications
  • Chemotherapy
  • Cisplatin
  • Head and neck cancer
  • Radiotherapy
  • Serum concentrations

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

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