Radiotherapy and Abscopal Effect:  Insight From the Past, Present and Future

Albert C. Chen; E. Brian Butler; Simon S. Lo; Bin Teh

doi:10.1007/s13566-015-0223-6

Radiotherapy and Abscopal Effect: Insight From the Past, Present and Future

Albert C. Chen, E. Brian Butler, Simon S. Lo, Bin Teh

Research output: Contribution to journal › Article

Abstract

The abscopal effect is a rare phenomenon in radiation
oncology where radiotherapy has a therapeutic effect at a
distance from the intended treatment field. This effect has
resulted in dramatic clinical responses in metastatic cancer
patients. Despite clinical reports describing this phenomenon
for over six decades, the abscopal effect is still not well
understood. In this systematic review, we summarize and
review the clinical and preclinical data that have investigated
the mechanisms of this effect and consider the potential of
exploiting its use in cancer care.

Original language	English (US)
Pages (from-to)	321-330
Number of pages	10
Journal	Journal of Radiation Oncology
Volume	4
DOIs	https://doi.org/10.1007/s13566-015-0223-6
State	Published - Oct 13 2015

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title = "Radiotherapy and Abscopal Effect: Insight From the Past, Present and Future",

abstract = "The abscopal effect is a rare phenomenon in radiationoncology where radiotherapy has a therapeutic effect at adistance from the intended treatment field. This effect hasresulted in dramatic clinical responses in metastatic cancerpatients. Despite clinical reports describing this phenomenonfor over six decades, the abscopal effect is still not wellunderstood. In this systematic review, we summarize andreview the clinical and preclinical data that have investigatedthe mechanisms of this effect and consider the potential ofexploiting its use in cancer care.",

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N2 - The abscopal effect is a rare phenomenon in radiationoncology where radiotherapy has a therapeutic effect at adistance from the intended treatment field. This effect hasresulted in dramatic clinical responses in metastatic cancerpatients. Despite clinical reports describing this phenomenonfor over six decades, the abscopal effect is still not wellunderstood. In this systematic review, we summarize andreview the clinical and preclinical data that have investigatedthe mechanisms of this effect and consider the potential ofexploiting its use in cancer care.

AB - The abscopal effect is a rare phenomenon in radiationoncology where radiotherapy has a therapeutic effect at adistance from the intended treatment field. This effect hasresulted in dramatic clinical responses in metastatic cancerpatients. Despite clinical reports describing this phenomenonfor over six decades, the abscopal effect is still not wellunderstood. In this systematic review, we summarize andreview the clinical and preclinical data that have investigatedthe mechanisms of this effect and consider the potential ofexploiting its use in cancer care.

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DO - 10.1007/s13566-015-0223-6

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