Radiotherapy and Abscopal Effect: Insight From the Past, Present and Future

Albert C. Chen, E. Brian Butler, Simon S. Lo, Bin Teh

Research output: Contribution to journalArticlepeer-review


The abscopal effect is a rare phenomenon in radiation
oncology where radiotherapy has a therapeutic effect at a
distance from the intended treatment field. This effect has
resulted in dramatic clinical responses in metastatic cancer
patients. Despite clinical reports describing this phenomenon
for over six decades, the abscopal effect is still not well
understood. In this systematic review, we summarize and
review the clinical and preclinical data that have investigated
the mechanisms of this effect and consider the potential of
exploiting its use in cancer care.
Original languageEnglish (US)
Pages (from-to)321-330
Number of pages10
JournalJournal of Radiation Oncology
StatePublished - Oct 13 2015


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