Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

Meixiang Yu; Anu J. Airaksinen; Antony D. Gee; Simo Lötjönen; Jyrki T. Kuikka; Jouko J. Vepsäläinen; Jukka Hiltunen; Kim A. Bergström

doi:10.1002/jlcr.619

Radiosynthesis of [¹²³I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

Meixiang Yu, Anu J. Airaksinen, Antony D. Gee, Simo Lötjönen, Jyrki T. Kuikka, Jouko J. Vepsäläinen, Jukka Hiltunen, Kim A. Bergström

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The radiosynthesis of a novel tropane derivative [¹²³I]KUC-25019, [[¹²³I] N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β (3′,4′-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the ¹²³I-labeling synthesis. The no-carrier-added ¹²³I-labeling has about 20% yield, the specific activity of [¹²³I]KUC-25019 is > 107 GBq/μmol and the radiochemical purity of [¹²³I] KUC-25019 is >95%.

Original language	English (US)
Pages (from-to)	1011-1017
Number of pages	7
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	45
Issue number	12
DOIs	https://doi.org/10.1002/jlcr.619
State	Published - Oct 30 2002

Keywords

I
Dopamine transporter
KUC-25019
SPET
Tropane analog

ASJC Scopus subject areas

Clinical Biochemistry
Molecular Medicine
Analytical Chemistry
Organic Chemistry
Drug Discovery
Pharmacology

Access to Document

10.1002/jlcr.619

Cite this

Yu, M., Airaksinen, A. J., Gee, A. D., Lötjönen, S., Kuikka, J. T., Vepsäläinen, J. J., Hiltunen, J., & Bergström, K. A. (2002). Radiosynthesis of [¹²³I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter. Journal of Labelled Compounds and Radiopharmaceuticals, 45(12), 1011-1017. https://doi.org/10.1002/jlcr.619

Radiosynthesis of [¹²³I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter. / Yu, Meixiang; Airaksinen, Anu J.; Gee, Antony D. et al.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 45, No. 12, 30.10.2002, p. 1011-1017.

Research output: Contribution to journal › Article › peer-review

Yu, M, Airaksinen, AJ, Gee, AD, Lötjönen, S, Kuikka, JT, Vepsäläinen, JJ, Hiltunen, J & Bergström, KA 2002, 'Radiosynthesis of [¹²³I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 45, no. 12, pp. 1011-1017. https://doi.org/10.1002/jlcr.619

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abstract = "The radiosynthesis of a novel tropane derivative [123I]KUC-25019, [[123I] N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β (3′,4′-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the 123I-labeling synthesis. The no-carrier-added 123I-labeling has about 20\% yield, the specific activity of [123I]KUC-25019 is > 107 GBq/μmol and the radiochemical purity of [123I] KUC-25019 is >95\%.",

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AU - Airaksinen, Anu J.

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