Radiosynthesis of [123I]N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3 β-(3′,4′-dichlorophenyl) nortropane as a potential SPET tracer for dopamine transporter

Meixiang Yu, Anu J. Airaksinen, Antony D. Gee, Simo Lötjönen, Jyrki T. Kuikka, Jouko J. Vepsäläinen, Jukka Hiltunen, Kim A. Bergström

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Abstract

The radiosynthesis of a novel tropane derivative [123I]KUC-25019, [[123I] N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β (3′,4′-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the 123I-labeling synthesis. The no-carrier-added 123I-labeling has about 20% yield, the specific activity of [123I]KUC-25019 is > 107 GBq/μmol and the radiochemical purity of [123I] KUC-25019 is >95%.

Original languageEnglish (US)
Pages (from-to)1011-1017
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume45
Issue number12
DOIs
StatePublished - Oct 30 2002

Keywords

  • I
  • Dopamine transporter
  • KUC-25019
  • SPET
  • Tropane analog

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Molecular Medicine
  • Analytical Chemistry
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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