Abstract
The radiosynthesis of a novel tropane derivative [123I]KUC-25019, [[123I] N-(3-iodoprop-(2E)-enyl)-2α-(imino-methyl)-3β (3′,4′-dichlorophenyl)nortropane], a potential inhibitor of the dopamine transporter is reported. The synthetic routes include the preparation of standard reference, the stannyl precursor and the 123I-labeling synthesis. The no-carrier-added 123I-labeling has about 20% yield, the specific activity of [123I]KUC-25019 is > 107 GBq/μmol and the radiochemical purity of [123I] KUC-25019 is >95%.
Original language | English (US) |
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Pages (from-to) | 1011-1017 |
Number of pages | 7 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 45 |
Issue number | 12 |
DOIs | |
State | Published - Oct 30 2002 |
Keywords
- I
- Dopamine transporter
- KUC-25019
- SPET
- Tropane analog
ASJC Scopus subject areas
- Clinical Biochemistry
- Molecular Medicine
- Analytical Chemistry
- Organic Chemistry
- Drug Discovery
- Pharmacology