Radical cystectomy versus chemoradiation for muscle-invasive bladder cancer: Impact of treatment facility and sociodemographics

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Background: The present study sought to compare the differences in practice patterns, as well as clinical outcomes for patients with muscle-invasive bladder cancer undergoing treatment with either radical cystectomy (RC) or concurrent chemoradiaiton (CRT). Patients and Methods: The National Cancer Data Base (NCDB) was queried for patients diagnosed with T2/T3/T4aN0M0 bladder cancer, between 2004-2013, that received definitive treatment with either RC or CRT. Results: 16,960 patients met the inclusion criteria; 1,450 (8.5%) underwent CRT, while 15,510 (91.5%) were treated with RC. Patients undergoing CRT were older, more likely to be female, African American, received treatment at an academic facility, and lived <20 miles of the treatment facility. CRT was associated with worse median OS (32.8 months vs. 36.1 months; p=0.0004). Conclusion: Older patients are more likely to undergo bladder preservation therapy, while those living farther away from treatment facilities are less likely to under CRT.

Original languageEnglish (US)
Pages (from-to)5603-5608
Number of pages6
JournalAnticancer Research
Volume37
Issue number10
DOIs
StatePublished - Oct 2017

Keywords

  • Bladder cancer
  • Bladder preservation
  • Chemoradiation
  • Chemotherapy
  • Cystectomy
  • Radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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