Radiation proctopathy in the treatment of prostate cancer

Amit K. Garg, Wei Yuan Mai, John E. McGary, Walter H. Grant, Edward Brian Butler, Bin S. Teh

Research output: Contribution to journalArticle

39 Scopus citations

Abstract

Purpose: To compile and review data on radiation proctopathy in the treatment of prostate cancer with respect to epidemiology, clinical manifestations, pathogenesis, risk factors, and treatment. Methods: Medical literature databases including PubMed and Medline were screened for pertinent reports, and critically analyzed for relevance in the scope of our purpose. Results: Rectal toxicity as a complication of radiotherapy has received attention over the past decade, especially with the advent of dose-escalation in prostate cancer treatment. A number of clinical criteria help to define acute and chronic radiation proctopathy, but lack of a unified grading scale makes comparing studies difficult. A variety of risk factors, related to either radiation delivery or patient, are the subject of intense study. Also, a variety of treatment options, including medical therapy, endoscopic treatments, and surgery have shown varied results, but a lack of large randomized trials evaluating their efficacy prevents forming concrete recommendations. Conclusion: Radiation proctopathy should be an important consideration for the clinician in the treatment of prostate cancer especially with dose escalation. With further study of possible risk factors, the advent of a standardized grading scale, and more randomized trials to evaluate treatments, patients and physicians will be better armed to make appropriate management decisions.

Original languageEnglish (US)
Pages (from-to)1294-1305
Number of pages12
JournalInternational Journal of Radiation Oncology Biology Physics
Volume66
Issue number5
DOIs
StatePublished - Dec 1 2006

Keywords

  • Dose escalation
  • Prostate cancer
  • Radiation proctopathy
  • Radiotherapy
  • Rectal toxicity

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Radiation

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