Radiation-induced lung injury

Lawrence B. Marks, Xiaoli Yu, Zjelko Vujaskovic, William Small, Rodney Folz, Mitchell S. Anscher

Research output: Contribution to journalArticlepeer-review

243 Scopus citations


Radiation therapy (RT) for thoracic-region tumors often causes lung injury. The incidence of lung toxicity depends on the method of assessment (eg, radiographs, patient's symptoms, or functional endpoints such as pulmonary function tests). Three-dimensional (3D) treatment planning tools provide dosimetric predictors for the risk of symptomatic RT-induced lung injury and allow for beams to be selected to minimize these risks. A variety of cytokines have been implicated as indicators/mediators of lung injury. Recent work suggests that injury-associated tissue hypoxia perpetuates further injury. Sophisticated planning/delivery methods, such as intensity modulation, plus radioprotectors such as amifostine, hold promise to reduce the incidence of RT-induced lung injury.

Original languageEnglish (US)
Pages (from-to)333-345
Number of pages13
JournalSeminars in Radiation Oncology
Issue number3
StatePublished - Jul 2003

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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