Radiation-Induced Liver Disease and Modern Radiotherapy

Eugene J. Koay, Dawn Owen, Prajnan Das

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


Modern radiotherapy techniques have enabled high focal doses of radiation to be delivered to patients with primary and secondary malignancies of the liver. The current clinical practice of radiation oncology has benefitted from decades of research that have informed how to achieve excellent local control and survival outcomes with minimal toxicities. Still, one of the most devastating consequences of radiation to the liver remains a challenge: radiation-induced liver disease (RILD). Here, we will review the current understanding of classic and nonclassic RILD from a clinical perspective, the evaluation and management of patients who are at risk of developing RILD, methods to reduce the likelihood of RILD using modern radiation techniques, and the diagnosis and treatment of radiation-related liver toxicities.

Original languageEnglish (US)
Pages (from-to)321-331
Number of pages11
JournalSeminars in Radiation Oncology
Issue number4
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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