Radiation dosimetry and biodistribution of 99mTc-ethylene dicysteine-deoxyglucose in patients with non-small-cell lung cancer

Naomi R. Schechter, William D. Erwin, David J. Yang, E. Edmund Kim, Reginald F. Munden, Kenneth Forster, Lina C. Taing, James D. Cox, Homer A. MacApinlac, Donald A. Podoloff

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Purpose: To assess the radiation dosimetry and biodistribution of 99mTc-labeled ethylene dicysteine deoxyglucose (99mTc-EC- DG) in patients with non-small-cell lung cancer (NSCLC). Methods: Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of 99mTc-EC-DG (925 MBq) in seven NSCLC patients. Radiation dosimetry, blood clearance and SPECT imaging of the primary tumor were assessed. Results: The critical organ was the bladder wall, with average radiation absorbed dose over all seven patients of 2.47×10-2 mGy/MBq. The average effective dose equivalent and effective dose were 6.20×10-3 mSv/MBq (6.89 mSv/1,110 MBq) and 5.90×10-3 mSv/MBq (6.54 mSv/1,110 MBq), respectively. The primary tumor was visualized with SPECT in six patients. On final pathology, one patient had a granuloma, which did not enhance with 99mTc-EC-DG. Conclusion: 99mTc-EC-DG has acceptable dosimetric and biodistribution properties as a diagnostic tumor-imaging agent. Future studies are planned to evaluate its diagnostic potential.

Original languageEnglish (US)
Pages (from-to)1583-1591
Number of pages9
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume36
Issue number10
DOIs
StatePublished - 2009

Keywords

  • Deoxyglucose
  • EC-DG
  • Glucosamine
  • Lung cancer
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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