Purpose: To assess the radiation dosimetry and biodistribution of 99mTc-labeled ethylene dicysteine deoxyglucose (99mTc-EC- DG) in patients with non-small-cell lung cancer (NSCLC). Methods: Serial whole-body scans were acquired 0, 2, 4, 6 and 24 h after injection of 99mTc-EC-DG (925 MBq) in seven NSCLC patients. Radiation dosimetry, blood clearance and SPECT imaging of the primary tumor were assessed. Results: The critical organ was the bladder wall, with average radiation absorbed dose over all seven patients of 2.47×10-2 mGy/MBq. The average effective dose equivalent and effective dose were 6.20×10-3 mSv/MBq (6.89 mSv/1,110 MBq) and 5.90×10-3 mSv/MBq (6.54 mSv/1,110 MBq), respectively. The primary tumor was visualized with SPECT in six patients. On final pathology, one patient had a granuloma, which did not enhance with 99mTc-EC-DG. Conclusion: 99mTc-EC-DG has acceptable dosimetric and biodistribution properties as a diagnostic tumor-imaging agent. Future studies are planned to evaluate its diagnostic potential.
|Original language||English (US)|
|Number of pages||9|
|Journal||European Journal of Nuclear Medicine and Molecular Imaging|
|State||Published - 2009|
- Lung cancer
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging