Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease

Research output: Contribution to journalArticle

Ciaran J. McMullan, Yuichiro Yano, George L. Bakris, Kazuomi Kario, Robert A. Phillips, John P. Forman

Ambulatory blood pressure parameters, nocturnal dipping and morning surge, are associated with cardiovascular outcomes in several populations. While significant variation exists between racial groups in ambulatory blood pressure measurements and the incidence of cardiovascular disease, the effect of race on the associations of dipping and morning surge with cardiovascular outcomes is unknown. In a prospective analysis of 197 African American and 197 Japanese individuals with non-diabetic chronic kidney disease matched by age and renal function, we analyzed the associations of dipping and morning surge with cardiovascular events for both races and assessed whether these relations differed by race. Higher sleep-trough morning surge was independently associated with cardiovascular events in Japanese (hazard ratio, 1.93 per 10 mm Hg; 95% confidence interval, 1.20-3.10) but not in African American participants, with race an effect modifier (P-value <.01). Dipping was not associated with cardiovascular events in either racial group. In individuals with chronic kidney disease, the association between morning surge and cardiovascular events appears to be dependent upon race, with higher morning surge a risk factors in Japanese but not in African Americans.

Original languageEnglish (US)
Pages (from-to)299-306
Number of pages8
JournalJournal of the American Society of Hypertension
Volume9
Issue number4
DOIs
StatePublished - Apr 1 2015

PMID: 25891362

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Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease. / McMullan, Ciaran J.; Yano, Yuichiro; Bakris, George L.; Kario, Kazuomi; Phillips, Robert A.; Forman, John P.

In: Journal of the American Society of Hypertension, Vol. 9, No. 4, 01.04.2015, p. 299-306.

Research output: Contribution to journalArticle

Harvard

McMullan, CJ, Yano, Y, Bakris, GL, Kario, K, Phillips, RA & Forman, JP 2015, 'Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease' Journal of the American Society of Hypertension, vol. 9, no. 4, pp. 299-306. https://doi.org/10.1016/j.jash.2015.02.005

APA

McMullan, C. J., Yano, Y., Bakris, G. L., Kario, K., Phillips, R. A., & Forman, J. P. (2015). Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease. Journal of the American Society of Hypertension, 9(4), 299-306. https://doi.org/10.1016/j.jash.2015.02.005

Vancouver

McMullan CJ, Yano Y, Bakris GL, Kario K, Phillips RA, Forman JP. Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease. Journal of the American Society of Hypertension. 2015 Apr 1;9(4):299-306. https://doi.org/10.1016/j.jash.2015.02.005

Author

McMullan, Ciaran J. ; Yano, Yuichiro ; Bakris, George L. ; Kario, Kazuomi ; Phillips, Robert A. ; Forman, John P. / Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease. In: Journal of the American Society of Hypertension. 2015 ; Vol. 9, No. 4. pp. 299-306.

BibTeX

@article{7985d88968d3476ab2bcfc66f3ed8361,
title = "Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease",
abstract = "Ambulatory blood pressure parameters, nocturnal dipping and morning surge, are associated with cardiovascular outcomes in several populations. While significant variation exists between racial groups in ambulatory blood pressure measurements and the incidence of cardiovascular disease, the effect of race on the associations of dipping and morning surge with cardiovascular outcomes is unknown. In a prospective analysis of 197 African American and 197 Japanese individuals with non-diabetic chronic kidney disease matched by age and renal function, we analyzed the associations of dipping and morning surge with cardiovascular events for both races and assessed whether these relations differed by race. Higher sleep-trough morning surge was independently associated with cardiovascular events in Japanese (hazard ratio, 1.93 per 10 mm Hg; 95{\%} confidence interval, 1.20-3.10) but not in African American participants, with race an effect modifier (P-value <.01). Dipping was not associated with cardiovascular events in either racial group. In individuals with chronic kidney disease, the association between morning surge and cardiovascular events appears to be dependent upon race, with higher morning surge a risk factors in Japanese but not in African Americans.",
keywords = "African Americans, Ambulatory blood pressure, Japanese, coronary artery disease, stroke",
author = "McMullan, {Ciaran J.} and Yuichiro Yano and Bakris, {George L.} and Kazuomi Kario and Phillips, {Robert A.} and Forman, {John P.}",
year = "2015",
month = "4",
day = "1",
doi = "10.1016/j.jash.2015.02.005",
language = "English (US)",
volume = "9",
pages = "299--306",
journal = "Journal of the American Society of Hypertension",
issn = "1933-1711",
publisher = "Elsevier Ireland Ltd",
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}

RIS

TY - JOUR

T1 - Racial impact of diurnal variations in blood pressure on cardiovascular events in chronic kidney disease

AU - McMullan, Ciaran J.

AU - Yano, Yuichiro

AU - Bakris, George L.

AU - Kario, Kazuomi

AU - Phillips, Robert A.

AU - Forman, John P.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Ambulatory blood pressure parameters, nocturnal dipping and morning surge, are associated with cardiovascular outcomes in several populations. While significant variation exists between racial groups in ambulatory blood pressure measurements and the incidence of cardiovascular disease, the effect of race on the associations of dipping and morning surge with cardiovascular outcomes is unknown. In a prospective analysis of 197 African American and 197 Japanese individuals with non-diabetic chronic kidney disease matched by age and renal function, we analyzed the associations of dipping and morning surge with cardiovascular events for both races and assessed whether these relations differed by race. Higher sleep-trough morning surge was independently associated with cardiovascular events in Japanese (hazard ratio, 1.93 per 10 mm Hg; 95% confidence interval, 1.20-3.10) but not in African American participants, with race an effect modifier (P-value <.01). Dipping was not associated with cardiovascular events in either racial group. In individuals with chronic kidney disease, the association between morning surge and cardiovascular events appears to be dependent upon race, with higher morning surge a risk factors in Japanese but not in African Americans.

AB - Ambulatory blood pressure parameters, nocturnal dipping and morning surge, are associated with cardiovascular outcomes in several populations. While significant variation exists between racial groups in ambulatory blood pressure measurements and the incidence of cardiovascular disease, the effect of race on the associations of dipping and morning surge with cardiovascular outcomes is unknown. In a prospective analysis of 197 African American and 197 Japanese individuals with non-diabetic chronic kidney disease matched by age and renal function, we analyzed the associations of dipping and morning surge with cardiovascular events for both races and assessed whether these relations differed by race. Higher sleep-trough morning surge was independently associated with cardiovascular events in Japanese (hazard ratio, 1.93 per 10 mm Hg; 95% confidence interval, 1.20-3.10) but not in African American participants, with race an effect modifier (P-value <.01). Dipping was not associated with cardiovascular events in either racial group. In individuals with chronic kidney disease, the association between morning surge and cardiovascular events appears to be dependent upon race, with higher morning surge a risk factors in Japanese but not in African Americans.

KW - African Americans

KW - Ambulatory blood pressure

KW - Japanese

KW - coronary artery disease

KW - stroke

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UR - http://www.scopus.com/inward/citedby.url?scp=84928401543&partnerID=8YFLogxK

U2 - 10.1016/j.jash.2015.02.005

DO - 10.1016/j.jash.2015.02.005

M3 - Article

VL - 9

SP - 299

EP - 306

JO - Journal of the American Society of Hypertension

T2 - Journal of the American Society of Hypertension

JF - Journal of the American Society of Hypertension

SN - 1933-1711

IS - 4

ER -

ID: 16810720