TY - JOUR
T1 - Quercetin offers cardioprotection against progression of experimental autoimmune myocarditis by suppression of oxidative and endoplasmic reticulum stress via endothelin-1/MAPK signalling
AU - Arumugam, Somasundaram
AU - Thandavarayan, Rajarajan A.
AU - Arozal, Wawaimuli
AU - Sari, Flori R.
AU - Giridharan, Vijayasree V.
AU - Soetikno, Vivian
AU - Palaniyandi, Suresh S.
AU - Harima, Meilei
AU - Suzuki, Kenji
AU - Nagata, Masaki
AU - Tagaki, Ritsuo
AU - Kodama, Makoto
AU - Watanabe, Kenichi
N1 - Funding Information:
This research was supported by a Yujin Memorial Grant, Ministry of Education, Culture, Sports, Science and Technology, Japan and by a grant from the promotion and Mutual Aid Corporation for Private Schools, Japan.
PY - 2012/2
Y1 - 2012/2
N2 - In order to test the hypothesis that treatment with quercetin at a dose of 10 mg/kg protects from the progression of experimental autoimmune myocarditis (EAM) to dilated cardiomyopathy (DCM), we have used the rat model of EAM induced by porcine cardiac myosin. Our results identified that the post-myocarditis rats suffered from elevated endoplasmic reticulum (ER) stress and adverse cardiac remodelling in the form of myocardial fibrosis, whereas the rats treated with quercetin have been protected from these changes as evidenced by the decreased myocardial levels of ER stress and fibrosis markers when compared with the vehicle-treated DCM rats. In addition, the myocardial dimensions and cardiac function were preserved significantly in the quercetin-treated rats in comparison with the DCM rats treated with vehicle alone. Interestingly, the rats treated with quercetin showed significant suppression of the myocardial endothelin-1 and also the mitogen activated protein kinases (MAPK) suggesting that the protection offered by quercetin treatment against progression of EAM involves the modulation of MAPK signalling cascade. Collectively, the present study provides data to support the role of quercetin in protecting the hearts of the rats with post myocarditis DCM.
AB - In order to test the hypothesis that treatment with quercetin at a dose of 10 mg/kg protects from the progression of experimental autoimmune myocarditis (EAM) to dilated cardiomyopathy (DCM), we have used the rat model of EAM induced by porcine cardiac myosin. Our results identified that the post-myocarditis rats suffered from elevated endoplasmic reticulum (ER) stress and adverse cardiac remodelling in the form of myocardial fibrosis, whereas the rats treated with quercetin have been protected from these changes as evidenced by the decreased myocardial levels of ER stress and fibrosis markers when compared with the vehicle-treated DCM rats. In addition, the myocardial dimensions and cardiac function were preserved significantly in the quercetin-treated rats in comparison with the DCM rats treated with vehicle alone. Interestingly, the rats treated with quercetin showed significant suppression of the myocardial endothelin-1 and also the mitogen activated protein kinases (MAPK) suggesting that the protection offered by quercetin treatment against progression of EAM involves the modulation of MAPK signalling cascade. Collectively, the present study provides data to support the role of quercetin in protecting the hearts of the rats with post myocarditis DCM.
KW - adverse cardiac remodelling
KW - apoptosis
KW - fibrosis
KW - mitogen activated protein kinase signalling
KW - oxidative stress
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U2 - 10.3109/10715762.2011.647010
DO - 10.3109/10715762.2011.647010
M3 - Article
C2 - 22145946
AN - SCOPUS:84863027430
SN - 1071-5762
VL - 46
SP - 154
EP - 163
JO - Free Radical Research
JF - Free Radical Research
IS - 2
ER -