@inbook{aa1e118d7ad44297a14fc0c6145ed5a8,
title = "Quantitative trait loci mapping",
abstract = "This chapter presents current methods for mapping quantitative trait loci (QTLs) in natural populations especially in humans. We discussed the experimental designs for QTL mapping, traditional methods adopted such as linkage mapping approaches and methods for linkage disequilibrium (LD) mapping. Multiple traits and interaction analysis are also outlined. The application of modern genomic approaches, which mainly exploit the microarray technology, into QTL mapping was detailed. The latter are very recent protocols and are less developed than linkage and association methods at present. The main focus of this chapter is technical issues although statistical issues are also covered to certain extent. Finally, we summarize the limitations of the current QTL approaches and discuss the solutions to certain problems.",
keywords = "Association, EQTL, Linkage, Linkage disequilibrium, Microarrays, QTL, Whole genome association.",
author = "Xiong, {Dong Hai} and Liu, {Jian Feng} and Guo, {Yan Fang} and Yan Guao and Yang, {Tie Lin} and Hui Jiang and Yuan Chen and Fang Yang and Recker, {Robert R.} and Deng, {Hong Wen}",
year = "2008",
doi = "10.1007/978-1-59745-104-8_16",
language = "English (US)",
isbn = "9781588298287",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "203--235",
booktitle = "Osteoporosis",
}