TY - JOUR
T1 - Quantitative phase-flow MR imaging in dogs by using standard sequences
T2 - Comparison with in vivo flow-meter measurements
AU - Pettigrew, R. I.
AU - Dannels, W.
AU - Galloway, J. R.
AU - Pearson, T.
AU - Millikan, W.
AU - Henderson, J. M.
AU - Peterson, J.
AU - Bernardino, M. E.
PY - 1987
Y1 - 1987
N2 - For evaluation of the feasibility and clinical potential of using the phase data from standard MR imaging sequences to measure blood flow, 11 vessels with diameters of 4 to 7 mm were imaged in seven dogs. The flow in either the superior mesenteric vein or the inferior vena cava was measured first at laparotomy (in ml/min) with electromagnetic flow meters. Immediately thereafter, these vessels were imaged by MR in 25-mm thick sections by using a standard spin echo (SE) 750/30 sequence with Philips 0.5-T imager. Previous phase-flow calibration of the imager and sequence allowed calculation of the blood flow rates from the phase images that were used to measure the vessels' cross-sectional areas and blood phase values. Comparison of the measurements obtained with each technique showed a significant correlation (r = .977, p < .05) between MR-imaging values and flow-meter measurements when the blood velocity was less than approximately 40 cm/sec, the known upper limit of the flow dynamic range for the MR hardware and sequence used. There was no correlation for blood velocities greater than 40 cm/sec. However, the range of blood flow velocities in dogs and man extends to more than 100 cm/sec. Thus, these results suggest that this technique might yield valuable adjunctive flow data in routine clinical imaging provided that improvements in hardware and software permit a larger dynamic range.
AB - For evaluation of the feasibility and clinical potential of using the phase data from standard MR imaging sequences to measure blood flow, 11 vessels with diameters of 4 to 7 mm were imaged in seven dogs. The flow in either the superior mesenteric vein or the inferior vena cava was measured first at laparotomy (in ml/min) with electromagnetic flow meters. Immediately thereafter, these vessels were imaged by MR in 25-mm thick sections by using a standard spin echo (SE) 750/30 sequence with Philips 0.5-T imager. Previous phase-flow calibration of the imager and sequence allowed calculation of the blood flow rates from the phase images that were used to measure the vessels' cross-sectional areas and blood phase values. Comparison of the measurements obtained with each technique showed a significant correlation (r = .977, p < .05) between MR-imaging values and flow-meter measurements when the blood velocity was less than approximately 40 cm/sec, the known upper limit of the flow dynamic range for the MR hardware and sequence used. There was no correlation for blood velocities greater than 40 cm/sec. However, the range of blood flow velocities in dogs and man extends to more than 100 cm/sec. Thus, these results suggest that this technique might yield valuable adjunctive flow data in routine clinical imaging provided that improvements in hardware and software permit a larger dynamic range.
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U2 - 10.2214/ajr.148.2.411
DO - 10.2214/ajr.148.2.411
M3 - Article
C2 - 2948376
AN - SCOPUS:0023113452
SN - 0361-803X
VL - 148
SP - 411
EP - 414
JO - American Journal of Roentgenology
JF - American Journal of Roentgenology
IS - 2
ER -