Quantitative gadolinium chelate-enhanced magnetic resonance imaging of normal endothelial barrier disruption from nanoparticle biophilicity interactions

Hemant Sarin, Steve H. Fung, Ariel S. Kanevsky, Haitao Wu, Colin M. Wilson, Howard Vo, Sungyoung Auh, Daniel Glen, Richard Reynolds

Research output: Contribution to journalConference articlepeer-review

Abstract

The biocompatibility of macromolecular therapeutics for enhanced passive permeation and retention remains a concern due to release kinetics or surface area properties. Dendritic conjugates functionalized with paramagnetic metal chelate with diameters less than (<) 12 nm and within the 8 to 10 nm size range can be utilized for high-resolution Gadolinium-based r1-1-adjusted dynamic magnetic resonance concentration mapping of solid tumor barrier hyper-permeability and study of contrast agent pharmacodynamics. Cationic dye- or doxorubicin-linked dendrimer nanoparticle surface-to-membrane channel or receptor biophilicity interaction results in abnormal contrast enhancement of endothelial barriers identifiable by transvenous dual flip angle T1-weighted blood-brain barrier imaging with higher-generation polyamidoamine interior core gadopentetic acid-chelated dendrimers with 1 + IS 1 + functionalized exteriors. The neutralization of nanoparticle exterior surface charge would afford biocompatibility in clinical transability across abnormal barrier endothelium pores for effective transvascular delivery.

Original languageEnglish (US)
Pages (from-to)3795-3799
Number of pages5
JournalMaterials Today: Proceedings
Volume45
DOIs
StatePublished - 2020
Event2nd International Symposium on Functional Nanomaterials in Industrial Applications: Academy - Industry Meet - Preston, United Kingdom
Duration: Apr 14 2020Apr 16 2020

Keywords

  • Cationotoxicity
  • Chemoxenobiotic
  • Endocytic effective pressure
  • General kinetic model
  • Molecular diameter
  • Theranostic agent
  • Vasomodulation

ASJC Scopus subject areas

  • Materials Science(all)

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