Abstract
The biocompatibility of macromolecular therapeutics for enhanced passive permeation and retention remains a concern due to release kinetics or surface area properties. Dendritic conjugates functionalized with paramagnetic metal chelate with diameters less than (<) 12 nm and within the 8 to 10 nm size range can be utilized for high-resolution Gadolinium-based r1-1-adjusted dynamic magnetic resonance concentration mapping of solid tumor barrier hyper-permeability and study of contrast agent pharmacodynamics. Cationic dye- or doxorubicin-linked dendrimer nanoparticle surface-to-membrane channel or receptor biophilicity interaction results in abnormal contrast enhancement of endothelial barriers identifiable by transvenous dual flip angle T1-weighted blood-brain barrier imaging with higher-generation polyamidoamine interior core gadopentetic acid-chelated dendrimers with 1 + IS 1 + functionalized exteriors. The neutralization of nanoparticle exterior surface charge would afford biocompatibility in clinical transability across abnormal barrier endothelium pores for effective transvascular delivery.
Original language | English (US) |
---|---|
Pages (from-to) | 3795-3799 |
Number of pages | 5 |
Journal | Materials Today: Proceedings |
Volume | 45 |
DOIs | |
State | Published - 2020 |
Event | 2nd International Symposium on Functional Nanomaterials in Industrial Applications: Academy - Industry Meet - Preston, United Kingdom Duration: Apr 14 2020 → Apr 16 2020 |
Keywords
- Cationotoxicity
- Chemoxenobiotic
- Endocytic effective pressure
- General kinetic model
- Molecular diameter
- Theranostic agent
- Vasomodulation
ASJC Scopus subject areas
- Materials Science(all)