Quantitative cytologic and histologic changes in the middle ear after the injection of nontypable Hemophilus influenzae endotoxin

Thomas F. DeMaria; Tatsuji Yamaguchi; David J. Lim

doi:10.1016/0196-0709(89)90006-9

Quantitative cytologic and histologic changes in the middle ear after the injection of nontypable Hemophilus influenzae endotoxin

Thomas F. DeMaria, Tatsuji Yamaguchi, David J. Lim

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

This study was undertaken to investigate and quantify the morphologic changes in the middle ear mucosa and connective tissue after the inoculation of graded doses (0.001 to 100 μg) of endotoxin prepared from Hemophilus influenzae. Histopathologic changes were observed in the middle ear mucosa in all animals. Marked bleeding and new bone formation in the submucosa were prominent at days 4 through 14. These findings indicate that the endotoxin from nontypable H influenzae is capable of inducing inflammation or pathologic changes in the middle ear mucosa and may play an important role in the pathogenesis of otitis media with effusion and its sequelae.

Original language	English (US)
Pages (from-to)	261-266
Number of pages	6
Journal	American Journal of Otolaryngology--Head and Neck Medicine and Surgery
Volume	10
Issue number	4
DOIs	https://doi.org/10.1016/0196-0709(89)90006-9
State	Published - 1989

Keywords

Endotoxin
Hemophilus influenzae
otitis media

ASJC Scopus subject areas

Otorhinolaryngology

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10.1016/0196-0709(89)90006-9

Cite this

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title = "Quantitative cytologic and histologic changes in the middle ear after the injection of nontypable Hemophilus influenzae endotoxin",

abstract = "This study was undertaken to investigate and quantify the morphologic changes in the middle ear mucosa and connective tissue after the inoculation of graded doses (0.001 to 100 μg) of endotoxin prepared from Hemophilus influenzae. Histopathologic changes were observed in the middle ear mucosa in all animals. Marked bleeding and new bone formation in the submucosa were prominent at days 4 through 14. These findings indicate that the endotoxin from nontypable H influenzae is capable of inducing inflammation or pathologic changes in the middle ear mucosa and may play an important role in the pathogenesis of otitis media with effusion and its sequelae.",

keywords = "Endotoxin, Hemophilus influenzae, otitis media",

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note = "Funding Information: Supported by grants from the National Institute of Neurological and Communication Disorders and Stroke of the National Institutes of Health (NS08854) and the Deafness Research Foundation.",

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T1 - Quantitative cytologic and histologic changes in the middle ear after the injection of nontypable Hemophilus influenzae endotoxin

AU - DeMaria, Thomas F.

AU - Yamaguchi, Tatsuji

AU - Lim, David J.

N1 - Funding Information: Supported by grants from the National Institute of Neurological and Communication Disorders and Stroke of the National Institutes of Health (NS08854) and the Deafness Research Foundation.

PY - 1989

Y1 - 1989

N2 - This study was undertaken to investigate and quantify the morphologic changes in the middle ear mucosa and connective tissue after the inoculation of graded doses (0.001 to 100 μg) of endotoxin prepared from Hemophilus influenzae. Histopathologic changes were observed in the middle ear mucosa in all animals. Marked bleeding and new bone formation in the submucosa were prominent at days 4 through 14. These findings indicate that the endotoxin from nontypable H influenzae is capable of inducing inflammation or pathologic changes in the middle ear mucosa and may play an important role in the pathogenesis of otitis media with effusion and its sequelae.

AB - This study was undertaken to investigate and quantify the morphologic changes in the middle ear mucosa and connective tissue after the inoculation of graded doses (0.001 to 100 μg) of endotoxin prepared from Hemophilus influenzae. Histopathologic changes were observed in the middle ear mucosa in all animals. Marked bleeding and new bone formation in the submucosa were prominent at days 4 through 14. These findings indicate that the endotoxin from nontypable H influenzae is capable of inducing inflammation or pathologic changes in the middle ear mucosa and may play an important role in the pathogenesis of otitis media with effusion and its sequelae.

KW - Endotoxin

KW - Hemophilus influenzae

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Quantitative cytologic and histologic changes in the middle ear after the injection of nontypable Hemophilus influenzae endotoxin

Abstract

Keywords

ASJC Scopus subject areas

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