Quantitative cytologic and histologic changes in the middle ear after the injection of nontypable Hemophilus influenzae endotoxin

Thomas F. DeMaria, Tatsuji Yamaguchi, David J. Lim

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

This study was undertaken to investigate and quantify the morphologic changes in the middle ear mucosa and connective tissue after the inoculation of graded doses (0.001 to 100 μg) of endotoxin prepared from Hemophilus influenzae. Histopathologic changes were observed in the middle ear mucosa in all animals. Marked bleeding and new bone formation in the submucosa were prominent at days 4 through 14. These findings indicate that the endotoxin from nontypable H influenzae is capable of inducing inflammation or pathologic changes in the middle ear mucosa and may play an important role in the pathogenesis of otitis media with effusion and its sequelae.

Original languageEnglish (US)
Pages (from-to)261-266
Number of pages6
JournalAmerican Journal of Otolaryngology--Head and Neck Medicine and Surgery
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1989

Keywords

  • Endotoxin
  • Hemophilus influenzae
  • otitis media

ASJC Scopus subject areas

  • Otorhinolaryngology

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