TY - JOUR
T1 - Quantifying Skin Uptake of Topicals After 1,927-nm and 1,440-nm Nonablative Fractional Diode Laser Treatment
AU - Wang, Jordan V.
AU - Friedman, Paul M.
AU - Agron, Samantha
AU - Konda, Adarsh
AU - Parker, Catherine
AU - Geronemus, Roy G.
N1 - Funding Information:
J. V. Wang, P. M. Friedman, A. Konda, C. Parker, and R. G. Geronemus serve as either investigators, employees, or stock holders or on the advisory board of Solta Medical. This study was supported by Solta Medical (a division of Bausch Health US, LLC).
Publisher Copyright:
© 2022 Lippincott Williams and Wilkins. All rights reserved.
PY - 2022/8/1
Y1 - 2022/8/1
N2 - BACKGROUNDAlthough the stratum corneum limits transdermal absorption of topicals, laser devices can enhance topical uptake by disrupting the skin barrier. Nonablative lasers are commonly used, but their effects on topical uptake should be quantified to optimize outcomes.OBJECTIVEThe objective of this study is to analyze transdermal uptake of 4 topicals after nonablative fractional diode laser pretreatment.METHODS AND MATERIALSHuman donor tissue was pretreated ex vivo with a nonablative fractional diode laser (1,927 nm or 1,440 nm, at varying treatment densities, powers, and peak energies) followed by application of either 2% salicylic acid, 10% ascorbic acid, over-the-counter mineral eye serum, or 4% hydroquinone. Topical uptake was quantified over 24 hours.RESULTSDespite lower power settings, pretreatment with the 1,927 nm wavelength was associated with greater uptake of 10% ascorbic acid, mineral eye serum, and 4% hydroquinone than the 1,440 nm wavelength. In addition, 1,440-nm laser pretreatment with higher density (320 microscopic treatment zones [MTZ]/cm2) and peak power (3 W) was associated with similar uptake but greater retention of 2% salicylic acid and greater uptake of 10% ascorbic acid than that with lower density (80 MTZ/cm2) and peak power (1.2 W).CONCLUSIONWhen using laser pretreatment, device settings should be adjusted to balance outcomes with potential side effects.
AB - BACKGROUNDAlthough the stratum corneum limits transdermal absorption of topicals, laser devices can enhance topical uptake by disrupting the skin barrier. Nonablative lasers are commonly used, but their effects on topical uptake should be quantified to optimize outcomes.OBJECTIVEThe objective of this study is to analyze transdermal uptake of 4 topicals after nonablative fractional diode laser pretreatment.METHODS AND MATERIALSHuman donor tissue was pretreated ex vivo with a nonablative fractional diode laser (1,927 nm or 1,440 nm, at varying treatment densities, powers, and peak energies) followed by application of either 2% salicylic acid, 10% ascorbic acid, over-the-counter mineral eye serum, or 4% hydroquinone. Topical uptake was quantified over 24 hours.RESULTSDespite lower power settings, pretreatment with the 1,927 nm wavelength was associated with greater uptake of 10% ascorbic acid, mineral eye serum, and 4% hydroquinone than the 1,440 nm wavelength. In addition, 1,440-nm laser pretreatment with higher density (320 microscopic treatment zones [MTZ]/cm2) and peak power (3 W) was associated with similar uptake but greater retention of 2% salicylic acid and greater uptake of 10% ascorbic acid than that with lower density (80 MTZ/cm2) and peak power (1.2 W).CONCLUSIONWhen using laser pretreatment, device settings should be adjusted to balance outcomes with potential side effects.
KW - Ascorbic Acid
KW - Humans
KW - Hydroquinones
KW - Laser Therapy/methods
KW - Lasers, Semiconductor/therapeutic use
KW - Salicylic Acid
KW - Skin
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U2 - 10.1097/DSS.0000000000003496
DO - 10.1097/DSS.0000000000003496
M3 - Article
C2 - 35583998
AN - SCOPUS:85135596394
SN - 1076-0512
VL - 48
SP - 822
EP - 826
JO - Dermatologic Surgery
JF - Dermatologic Surgery
IS - 8
ER -