Quantifying permeability of glucose in normal and atherosclerotic pig aorta in vitro using optical coherence tomography

Mohamad G. Ghosn, Esteban Carbajal, Natasha Befrui, Valery V. Tuchin, Kirill V. Larin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

High in-depth resolution imaging, such as Optical Coherence Tomography, could be the next frontier in noninvasive quantification of diffusion in epithelial tissues. In this study we employed OCT in a method that could help differentiate various forms of atherosclerosis and distinguish between normal and diseased tissue. The diffusion of glucose solution in normal and diseased pig aorta in vitro was monitored and the permeability coefficient was calculated. The results suggest that this OCT method may have high potential for early detection of tissue abnormalities while used in diffusion studies.

Original languageEnglish (US)
Title of host publicationCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
DOIs
StatePublished - 2008
EventCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII - San Jose, CA, United States
Duration: Jan 21 2008Jan 23 2008

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6847
ISSN (Print)1605-7422

Conference

ConferenceCoherence Domain Optical Methods and Optical Coherence Tomography in Biomedicine XII
Country/TerritoryUnited States
CitySan Jose, CA
Period1/21/081/23/08

Keywords

  • Aorta
  • Atherosclerosis
  • Diffusion
  • Glucose
  • Optical coherence tomography
  • Permeability coefficient

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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