TY - JOUR
T1 - Quantification of myocardial perfusion by MRI after coronary occlusion
AU - Vallée, Jean Paul M.
AU - Sostman, H. Dirk
AU - MacFall, James R.
AU - DeGrado, Timothy R.
AU - Zhang, Jian
AU - Sebbag, Laurent
AU - Cobb, Fred R.
AU - Wheeler, Ted
AU - Hedlund, Larry W.
AU - Turkington, Timothy G.
AU - Spritzer, Charles E.
AU - Coleman, R. Edward
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1998/8
Y1 - 1998/8
N2 - The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI- derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.
AB - The objectives of this study were to define the relationship between the first order constant of Gd-DTPA transfer (K1) and the myocardial blood flow (MBF) at rest and to compare it with an equivalent relationship obtained for positron emission tomography (PET). In a canine model of permanent coronary occlusion (n = 4), myocardial and blood time concentration curves obtained by 13N-ammonia PET and Gd-DTPA-enhanced MRI were fitted by a one-compartment model to determine K1. A linear relationship was observed between MRI- derived K1 and MBF measured by microspheres (K1 = 0.88 x flow -0.015, R = 0.95), which compares favorably with the equivalent relationship derived from PET (K1 = 0.74 x flow +0.16, R = 0.88). The results of this preliminary study suggest that, at rest and distal to a permanently occluded coronary artery, myocardial perfusion quantification by MRI is possible and can challenge PET.
KW - Blood flow
KW - Magnetic resonance imaging
KW - Myocardial infarction
KW - Radioisotopes
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U2 - 10.1002/mrm.1910400215
DO - 10.1002/mrm.1910400215
M3 - Article
C2 - 9702711
AN - SCOPUS:7344268000
SN - 0740-3194
VL - 40
SP - 287
EP - 297
JO - Magnetic Resonance in Medicine
JF - Magnetic Resonance in Medicine
IS - 2
ER -