Quality control practices for chemistry and immunochemistry in a cohort of 21 large academic medical centers

Matthew W. Rosenbaum, James G. Flood, Stacy E.F. Melanson, Nikola A. Baumann, Mark A. Marzinke, Alex J. Rai, Joshua Hayden, Alan H.B. Wu, Megan Ladror, Mark S. Lifshitz, Mitchell G. Scott, Octavia M. Peck-Palmer, Raffick Bowen, Nikolina Babic, Kimia Sobhani, Donald Giacherio, Gregary T. Bocsi, Daniel S. Herman, Ping Wang, John ToffalettiElizabeth Handel, Kathleen A. Kelly, Sami Albeiroti, Sihe Wang, Melissa Zimmer, Brandon Driver, Xin Yi, Clayton Wilburn, Kent B. Lewandrowski

Research output: Contribution to journalArticlepeer-review

41 Scopus citations


Objectives In the United States, minimum standards for quality control (QC) are specified in federal law under the Clinical Laboratory Improvement Amendment and its revisions. Beyond meeting this required standard, laboratories have flexibility to determine their overall QC program. Methods We surveyed chemistry and immunochemistry QC procedures at 21 clinical laboratories within leading academic medical centers to assess if standardized QC practices exist for chemistry and immunochemistry testing. Results We observed significant variation and unexpected similarities in practice across laboratories, including QC frequency, cutoffs, number of levels analyzed, and other features. Conclusions This variation in practice indicates an opportunity exists to establish an evidence-based approach to QC that can be generalized across institutions.

Original languageEnglish (US)
Pages (from-to)96-104
Number of pages9
JournalAmerican Journal of Clinical Pathology
Issue number2
StatePublished - Jul 3 2018


  • Chemistry
  • Immunochemistry
  • Quality control
  • Quality control rules
  • Westgard rules

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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