Putative Physiopathological Explanation for the "Sock Sign" in Bone Scans

Carole de Vaugelade, Jean Baptiste Pinaquy, Philippe Fernandez, Laurence Bordenave, Elif Hindie, Paolo Zanotti-Fregonara

Research output: Contribution to journalArticlepeer-review


Four patients were referred to our department to undergo a bone scan for suspected reflex sympathetic dystrophy in the upper limbs. After TC-HMDP injection in the foot, they developed a "sock sign," defined by highly increased uptake in the injected lower limb. The sock sign has been previously described in only 1 case in the literature and attributed to intra-arterial injection. Our images suggest that the sock sign might instead be the consequence of tracer extravasation at the injection site.

Original languageEnglish (US)
Pages (from-to)e420-e421
JournalClinical Nuclear Medicine
Issue number9
StatePublished - Sep 1 2016

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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