TY - JOUR
T1 - Pulsed doppler signal processing for use in mice
T2 - Applications
AU - Reddy, Anilkumar K.
AU - Taffet, George
AU - Li, Yi Heng
AU - Lim, Sang Wook
AU - Pham, Thuy T.
AU - Pocius, Jennifer S.
AU - Entman, Mark L.
AU - Michael, Lloyd H.
AU - Hartley, Craig J.
N1 - Funding Information:
Manuscript received August 20, 2004; revised March 26, 2005. This work was supported in part by National Institutes of Health under Grant HL-52364, Grant HL-22512, and Grant AG-13251, and in part by the Texas Advanced Technology Program. The work of Y.-H. Li was supported in part by a grant from National Science Council, Taipei, Taiwan, and the College of Medicine, National Cheng Kung University, Tainan, Taiwan. Dr. Lim was supported by Pochon CHA University, South Korea. Asterisk indicates corresponding author. *A. K. Reddy is with the Baylor College of Medicine, Houston, TX, 77030 USA (e-mail: [email protected]).
PY - 2005/10
Y1 - 2005/10
N2 - We have developed a high-frequency, high-resolution Doppler spectrum analyzer (DSPW) and compared its performance against an adapted clinical Medasonics spectrum analyzer (MSA) and a zero-crossing interval histogram (ZCIH) used previously by us to evaluate cardiovascular physiology in mice. The aortic velocity (means ± SE: 92.7 ± 2.5 versus 82.2 ± 1.8 cm/s) and aortic acceleration (8194 ± 319 versus 5178 ± 191 cm/s 2) determined by the DSPW were significantly higher compared to those by the MSA. Aortic ejection time was shorter (48.3 ± 0.9 versus 64.6 ± 1.8 ms) and the isovolumic relaxation was longer (17.6 ± 0.6 versus 13.5 ± 0.6 ms) when determined by the DSPW because it generates shorter temporal widths in the velocity spectra when compared to the MSA. These data indicate that the performance of the DSPW in evaluating cardiovascular physiology was better than that of the MSA. There were no significant differences between the aortic pulse wave velocity determined by using the ZCIH (391 ± 16 cm/s) and the DSPW (394 ± 20 cm/s). Besides monitoring cardiac function, we have used the DSPW for studying peripheral vascular physiology in normal, transgenic, and surgical models of mice. Several applications such as the detection of high stenotic jet velocities (>4 m/s), vortex shedding frequencies (250 Hz), and subtle changes in wave shapes in peripheral vessels which could not obtained with clinical Doppler systems are now made possible with the DSPW.
AB - We have developed a high-frequency, high-resolution Doppler spectrum analyzer (DSPW) and compared its performance against an adapted clinical Medasonics spectrum analyzer (MSA) and a zero-crossing interval histogram (ZCIH) used previously by us to evaluate cardiovascular physiology in mice. The aortic velocity (means ± SE: 92.7 ± 2.5 versus 82.2 ± 1.8 cm/s) and aortic acceleration (8194 ± 319 versus 5178 ± 191 cm/s 2) determined by the DSPW were significantly higher compared to those by the MSA. Aortic ejection time was shorter (48.3 ± 0.9 versus 64.6 ± 1.8 ms) and the isovolumic relaxation was longer (17.6 ± 0.6 versus 13.5 ± 0.6 ms) when determined by the DSPW because it generates shorter temporal widths in the velocity spectra when compared to the MSA. These data indicate that the performance of the DSPW in evaluating cardiovascular physiology was better than that of the MSA. There were no significant differences between the aortic pulse wave velocity determined by using the ZCIH (391 ± 16 cm/s) and the DSPW (394 ± 20 cm/s). Besides monitoring cardiac function, we have used the DSPW for studying peripheral vascular physiology in normal, transgenic, and surgical models of mice. Several applications such as the detection of high stenotic jet velocities (>4 m/s), vortex shedding frequencies (250 Hz), and subtle changes in wave shapes in peripheral vessels which could not obtained with clinical Doppler systems are now made possible with the DSPW.
KW - High-frequency pulsed Doppler ultrasound
KW - Mouse cardiac function
KW - Mouse cardiovascular physiology
KW - Pulse-wave velocity
KW - Stenotic jet velocities
KW - Vortex shedding frequencies
UR - http://www.scopus.com/inward/record.url?scp=26444501984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26444501984&partnerID=8YFLogxK
U2 - 10.1109/TBME.2005.855709
DO - 10.1109/TBME.2005.855709
M3 - Article
C2 - 16235663
AN - SCOPUS:26444501984
SN - 0018-9294
VL - 52
SP - 1771
EP - 1783
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 10
ER -