Pulmonary papillary adenoma a case report and review of the literature

Kristine M. Cornejo, Min Shi, Ali Akalin, Karl Uy, Philip T. Cagle, Armando E. Fraire

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Pulmonary papillary adenomas are rare neoplasms that predominantly occur in the periphery of the lung. We describe a 24-year-old male with a 6.0-cm spherical mass found incidentally at the periphery of the left upper lobe by imaging. Enucleation of the neoplasm was performed with intraoperative frozen section analysis. The tumor histologically showed papillary proliferations containing fibrovascular cores lined by a single layer of tumor cells that lacked atypia, mitoses, or necrosis. The histologic features were consistent with a pulmonary papillary adenoma. Pulmonary papillary adenoma was previously considered to be a benign entity. However, because of its invasive growth pattern, it has been suggested that this neoplasm has intermediate malignant potential. The clinicopathologic features and differential diagnosis of this unusual neoplasm is discussed with a review of the English literature.

Original languageEnglish (US)
Pages (from-to)52-57
Number of pages6
JournalJournal of Bronchology and Interventional Pulmonology
Issue number1
StatePublished - Jan 2013


  • Bronchiolar papilloma
  • Clara cell adenoma
  • Papillary adenoma
  • Type 2 pneumocytes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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