TY - JOUR
T1 - Pulmonary invasive aspergillosis in patients infected with the human immunodeficiency virus
T2 - Report of two cases
AU - Mylonakis, Eleftherios
AU - Mileno, Maria D.
AU - Flanigan, Timothy
AU - De Orchis, Douglas F.
AU - Rich, Josiah
PY - 1998
Y1 - 1998
N2 - Patients infected with the human immunodeficiency virus (HIV) have an increased frequency of invasive aspergillosis. We report two cases of invasive pulmonary aspergillosis in patients infected with HIV. Patients had less than 10 CD4 (helper cell) cells/mm3 (2/2), presented with fever (2/2), dyspnea (1/2), and abnormal chest radiograph (2/2). Diagnosis was established by transbronchial biopsy (1/2) and autopsy (1/2). Patients died in spite of treatment with intravenous deoxycholate amphotericin B. Prognosis of invasive pulmonary aspergillosis among patients infected with HIV remains dismal, even with aggressive antifungal treatment.
AB - Patients infected with the human immunodeficiency virus (HIV) have an increased frequency of invasive aspergillosis. We report two cases of invasive pulmonary aspergillosis in patients infected with HIV. Patients had less than 10 CD4 (helper cell) cells/mm3 (2/2), presented with fever (2/2), dyspnea (1/2), and abnormal chest radiograph (2/2). Diagnosis was established by transbronchial biopsy (1/2) and autopsy (1/2). Patients died in spite of treatment with intravenous deoxycholate amphotericin B. Prognosis of invasive pulmonary aspergillosis among patients infected with HIV remains dismal, even with aggressive antifungal treatment.
UR - http://www.scopus.com/inward/record.url?scp=0031892711&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031892711&partnerID=8YFLogxK
U2 - 10.1016/S0147-9563(98)90071-1
DO - 10.1016/S0147-9563(98)90071-1
M3 - Article
C2 - 9493885
AN - SCOPUS:0031892711
SN - 0147-9563
VL - 27
SP - 63
EP - 66
JO - Heart and Lung: Journal of Acute and Critical Care
JF - Heart and Lung: Journal of Acute and Critical Care
IS - 1
ER -