Pulmonary arterial hypertension in pregnant women

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling that limits the ability of the pulmonary vascular bed to withstand the physiological changes of pregnancy. Historically, pregnancy in PAH carries a high risk to the parturient. Normal pulmonary vasculature can withstand the hemodynamic and physiological changes associated with pregnancy without the development of respiratory symptomatology. However, in the presence of pulmonary vascular remodeling the capacity to handle these changes is compromised. During pregnancy, increase in cardiac output from the increased intravascular volume can lead to right heart failure. Therefore, all patients with PAH of childbearing potential should receive preconception counseling and be advised to use two methods of contraception. Patients with PAH should be advised against continuing pregnancy if they do become pregnant. According to the literature, deterioration in pregnancy mainly occurs in the second trimester and early in the third trimester; immediately postpartum is the most critical time for patients with PAH. In this review, we will discuss the recent advances in the management of parturient patients with PAH.

Original languageEnglish (US)
Pages (from-to)51-63
Number of pages13
JournalTherapeutic Advances in Respiratory Disease
Volume7
Issue number1
DOIs
StatePublished - Feb 2013

Keywords

  • Cesarean section
  • anesthesia
  • echocardiogram
  • pregnancy
  • pulmonary arterial hypertension
  • right heart failure
  • vaginal delivery

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Pharmacology (medical)

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