Pulmonary alveolar proteinosis in a kidney transplant: A rare complication of sirolimus

Huseyin Kadikoy, Michael Paolini, Katafan Achkar, Wadi N. Suki, A. Osama Gaber, Nabeel Anwar, Abdallah Jeroudi, Roberto Barrios, Abdul Abdellatif

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Pulmonary alveolar proteinosis (PAP) has been associated with the immunosuppressant sirolimus in transplant patients. PAP is a progressive lung disease characterized by the accumulation of surfactant-like material in the lungs leading to decreased pulmonary function with shortness of breath and cough as common symptoms. We report a rare case of sirolimus-associated PAP in a kidney transplant recipient with a history of end-stage renal disease secondary to haemolytic uraemic syndrome (HUS) and review of the literature. Discontinuation of sirolimus and initiation of tacrolimus led to resolution of PAP without recurrence of HUS.

Original languageEnglish (US)
Pages (from-to)2795-2798
Number of pages4
JournalNephrology Dialysis Transplantation
Issue number8
StatePublished - Aug 2010


  • haemolytic uraemic syndrome
  • kidney transplant
  • pulmonary alveolar proteinosis
  • sirolimus
  • tacrolimus

ASJC Scopus subject areas

  • Nephrology
  • Transplantation


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