Proximal-type epithelioid sarcoma: Case report and result of comparative genomic hybridization

Mi Woo Lee, Kowan Ja Jee, Jae Yoon Ro, Deuk Pyo Lee, Jee Ho Choi, Kee Chan Moon, Jai Kyoung Koh

Research output: Contribution to journalArticle

15 Scopus citations

Abstract

Background: Epithelioid sarcoma is a rare mesenchymal neoplasm. Recently, a more aggressive, so-called 'proximal type' epithelioid sarcoma has been described. Clinical case: A 40-year-old-woman presented with 5 x 4 cm, erythematous, indurated, non-movable, painful mass on the pubic area. Histopathology demonstrated diffuse tumor-cell infiltration into the subcutaneous and fascia, which was consisted of prominent epithelioid cells and scattered rhabdoid cells. A multinodular growth pattern or granulomatous appearance with central necrosis was not observed. The tumor cells showed positive reactions for vimentin, cytokeratin (AE1/AE3), and CD34. Despite the surgery, left inguinal mass with lymphadenopathy occurred one month later. We also carried out comparative genomic hybridization (CGH) with tumor cells. CGH revealed chromosomal gain of 5q32-qter, 12q24-qter, and 22q. Conclusion: We report a case of proximal-type of epithelioid sarcoma, which showed the chromosomal gains of 5q32-qter, 12q24-qter, and 22q by CGH.

Original languageEnglish (US)
Pages (from-to)67-71
Number of pages5
JournalJournal of Cutaneous Pathology
Volume31
Issue number1
DOIs
StatePublished - Jan 2004

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Dermatology

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