Proximal aortic diameter evolution in hypertensive patients with mild-to-moderate aortic dilatation: A 5-year follow-up experience

Dario Leone, Andrea Cina, Francesco Tosello, Luca Sabia, Fabrizio Vallelonga, Eleonora Avenatti, Anna Astarita, Giulia Mingrone, Franco Veglio, Luca Ridolfi, Alberto Milan

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Background:Aortic dilatation is common in hypertensive patients and is associated with higher risk of cardiovascular events. Parameters predicting further dilatation during lifetime are poorly understood.Aim:To predict the midterm aortic diameter evolution in a cohort of hypertensive patients with known aortic dilatation at Sinus of Valsalva (SOV) level.Methods:We prospectively analyzed a cohort of essential hypertensive outpatients without any other known risk factor for aortic dilatation. They underwent serial echocardiographic evaluations from 2003 to 2016.Results:Two hundred and forty-two hypertensive outpatients with a mild-to-moderate (37-53 mm) aortic dilatation were followed up for at least 5 years. Mean growth rate was 0.08 ± 0.35 mm/year. No clinical or anthropometric parameters were significantly different in patients with and without aortic diameter increase. Aortic z score (number of standard deviations from the average value observed in the general population) at baseline was inversely associated with growth rate (R20.04, P < 0.05). Aortic diameter at first visit, demographic and echocardiographic variables were major determinants of aortic diameter at second visit, accounting for about 90% of its total variability.Conclusion:Mean growth rate of proximal aorta in hypertensive patients with known aortic dilatation was of about 0.1 mm/year. Dilatation over time is slower in patients with increased rather than normal aortic z score. Eventually, it could be possible to reliably predict aortic diameter at few months from first visit.

Original languageEnglish (US)
Pages (from-to)716-722
Number of pages7
JournalJournal of Hypertension
Issue number4
StatePublished - Apr 1 2020


  • aorta
  • diagnosis
  • follow-up
  • hypertension
  • hypertensive patients
  • mild-to-moderate aortic ectasia
  • proximal thoracic
  • transthoracic echocardiography

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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