Proton Pump Inhibitors Accelerate Endothelial Senescence

Gautham Yepuri, Roman Sukhovershin, Timo Z. Nazari-Shafti, Michael Petrascheck, Yohannes T. Ghebre, John P. Cooke

Research output: Contribution to journalArticlepeer-review

102 Scopus citations


Rationale: Proton pump inhibitors (PPIs) are popular drugs for gastroesophageal reflux, which are now available for long-term use without medical supervision. Recent reports suggest that PPI use is associated with cardiovascular, renal, and neurological morbidity. Objective: To study the long-term effect of PPIs on endothelial dysfunction and senescence and investigate the mechanism involved in PPI-induced vascular dysfunction. Methods and Results: Chronic exposure to PPIs impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. Conclusions: Our data may provide a unifying mechanism for the association of PPI use with increased risk of cardiovascular, renal, and neurological morbidity and mortality.

Original languageEnglish (US)
Pages (from-to)e36-e42
JournalCirculation Research
Issue number12
StatePublished - Jun 10 2016


  • aging
  • cardiovascular diseases
  • proteostasis deficiencies
  • proton pump inhibitors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine


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