Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Sadhna Phanse; Cuihong Wan; Blake Borgeson; Fan Tu; Kevin Drew; Greg Clark; Xuejian Xiong; Olga Kagan; Julian Kwan; Alexandr Bezginov; Kyle Chessman; Swati Pal; Graham Cromar; Ophelia Papoulas; Zuyao Ni; Daniel R. Boutz; Snejana Stoilova; Pierre C. Havugimana; Xinghua Guo; Ramy H. Malty; Mihail Sarov; Jack Greenblatt; Mohan Babu; W. Brent Derry; Elisabeth R. Tillier; John B. Wallingford; John Parkinson; Edward M. Marcotte; Andrew Emili

doi:10.1016/j.dib.2015.11.062

Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Sadhna Phanse, Cuihong Wan, Blake Borgeson, Fan Tu, Kevin Drew, Greg Clark, Xuejian Xiong, Olga Kagan, Julian Kwan, Alexandr Bezginov, Kyle Chessman, Swati Pal, Graham Cromar, Ophelia Papoulas, Zuyao Ni, Daniel R. Boutz, Snejana Stoilova, Pierre C. Havugimana, Xinghua Guo, Ramy H. MaltyMihail Sarov, Jack Greenblatt, Mohan Babu, W. Brent Derry, Elisabeth R. Tillier, John B. Wallingford, John Parkinson, Edward M. Marcotte, Andrew Emili

Houston Methodist

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (PXD002319-PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1].

Original language	English (US)
Pages (from-to)	715-721
Number of pages	7
Journal	Data in Brief
Volume	6
DOIs	https://doi.org/10.1016/j.dib.2015.11.062
State	Published - Mar 1 2016

Keywords

Biochemical
Fractionation
Metazoa
Protein complexes
Proteomics

ASJC Scopus subject areas

General

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10.1016/j.dib.2015.11.062

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Phanse, S., Wan, C., Borgeson, B., Tu, F., Drew, K., Clark, G., Xiong, X., Kagan, O., Kwan, J., Bezginov, A., Chessman, K., Pal, S., Cromar, G., Papoulas, O., Ni, Z., Boutz, D. R., Stoilova, S., Havugimana, P. C., Guo, X., ... Emili, A. (2016). Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes. Data in Brief, 6, 715-721. https://doi.org/10.1016/j.dib.2015.11.062

Phanse, S, Wan, C, Borgeson, B, Tu, F, Drew, K, Clark, G, Xiong, X, Kagan, O, Kwan, J, Bezginov, A, Chessman, K, Pal, S, Cromar, G, Papoulas, O, Ni, Z, Boutz, DR, Stoilova, S, Havugimana, PC, Guo, X, Malty, RH, Sarov, M, Greenblatt, J, Babu, M, Derry, WB, Tillier, ER, Wallingford, JB, Parkinson, J, Marcotte, EM & Emili, A 2016, 'Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes', Data in Brief, vol. 6, pp. 715-721. https://doi.org/10.1016/j.dib.2015.11.062

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title = "Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes",

abstract = "Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (PXD002319-PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1].",

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author = "Sadhna Phanse and Cuihong Wan and Blake Borgeson and Fan Tu and Kevin Drew and Greg Clark and Xuejian Xiong and Olga Kagan and Julian Kwan and Alexandr Bezginov and Kyle Chessman and Swati Pal and Graham Cromar and Ophelia Papoulas and Zuyao Ni and Boutz, \{Daniel R.\} and Snejana Stoilova and Havugimana, \{Pierre C.\} and Xinghua Guo and Malty, \{Ramy H.\} and Mihail Sarov and Jack Greenblatt and Mohan Babu and Derry, \{W. Brent\} and Tillier, \{Elisabeth R.\} and Wallingford, \{John B.\} and John Parkinson and Marcotte, \{Edward M.\} and Andrew Emili",

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doi = "10.1016/j.dib.2015.11.062",

language = "English (US)",

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AU - Phanse, Sadhna

AU - Wan, Cuihong

AU - Borgeson, Blake

AU - Tu, Fan

AU - Drew, Kevin

AU - Clark, Greg

AU - Xiong, Xuejian

AU - Kagan, Olga

AU - Kwan, Julian

AU - Bezginov, Alexandr

AU - Chessman, Kyle

AU - Pal, Swati

AU - Cromar, Graham

AU - Papoulas, Ophelia

AU - Ni, Zuyao

AU - Boutz, Daniel R.

AU - Stoilova, Snejana

AU - Havugimana, Pierre C.

AU - Guo, Xinghua

AU - Malty, Ramy H.

AU - Sarov, Mihail

AU - Greenblatt, Jack

AU - Babu, Mohan

AU - Derry, W. Brent

AU - Tillier, Elisabeth R.

AU - Wallingford, John B.

AU - Parkinson, John

AU - Marcotte, Edward M.

AU - Emili, Andrew

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (PXD002319-PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1].

AB - Our analysis examines the conservation of multiprotein complexes among metazoa through use of high resolution biochemical fractionation and precision mass spectrometry applied to soluble cell extracts from 5 representative model organisms Caenorhabditis elegans, Drosophila melanogaster, Mus musculus, Strongylocentrotus purpuratus, and Homo sapiens. The interaction network obtained from the data was validated globally in 4 distant species (Xenopus laevis, Nematostella vectensis, Dictyostelium discoideum, Saccharomyces cerevisiae) and locally by targeted affinity-purification experiments. Here we provide details of our massive set of supporting biochemical fractionation data available via ProteomeXchange (PXD002319-PXD002328), PPIs via BioGRID (185267); and interaction network projections via (http://metazoa.med.utoronto.ca) made fully accessible to allow further exploration. The datasets here are related to the research article on metazoan macromolecular complexes in Nature [1].

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KW - Fractionation

KW - Metazoa

KW - Protein complexes

KW - Proteomics

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VL - 6

SP - 715

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JO - Data in Brief

JF - Data in Brief

ER -

Proteome-wide dataset supporting the study of ancient metazoan macromolecular complexes

Abstract

Keywords

ASJC Scopus subject areas

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