Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

P Lorenzo Bozzelli; Seham Alaiyed; Eunyoung Kim; Sonia Villapol; Katherine Conant

doi:10.1155/2018/5735789

Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

P Lorenzo Bozzelli, Seham Alaiyed, Eunyoung Kim, Sonia Villapol, Katherine Conant

Research output: Contribution to journal › Review article › peer-review

65 Scopus citations

Abstract

The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus. It is thus apposed to sites at which PV neurons receive synaptic input. Emerging evidence suggests that changes in PNN integrity may affect glutamatergic input to PV interneurons, a population that is critical for the expression of synchronous neuronal population discharges that occur with gamma oscillations and sharp-wave ripples. The present review is focused on the composition of PNNs, posttranslation modulation of PNN components by sulfation and proteolysis, PNN alterations in disease, and potential effects of PNN remodeling on neuronal plasticity at the single-cell and population level.

Original language	English (US)
Article number	5735789
Pages (from-to)	5735789
Journal	Neural Plasticity
Volume	2018
DOIs	https://doi.org/10.1155/2018/5735789
State	Published - Jan 1 2018

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1155/2018/5735789

Cite this

@article{453d20f1c5464770abebd4a0cabc5ed2,

title = "Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics",

abstract = "The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus. It is thus apposed to sites at which PV neurons receive synaptic input. Emerging evidence suggests that changes in PNN integrity may affect glutamatergic input to PV interneurons, a population that is critical for the expression of synchronous neuronal population discharges that occur with gamma oscillations and sharp-wave ripples. The present review is focused on the composition of PNNs, posttranslation modulation of PNN components by sulfation and proteolysis, PNN alterations in disease, and potential effects of PNN remodeling on neuronal plasticity at the single-cell and population level.",

author = "{Lorenzo Bozzelli}, P and Seham Alaiyed and Eunyoung Kim and Sonia Villapol and Katherine Conant",

year = "2018",

month = jan,

day = "1",

doi = "10.1155/2018/5735789",

language = "English (US)",

volume = "2018",

pages = "5735789",

journal = "Neural Plasticity",

issn = "2090-5904",

publisher = "Wiley",

}

TY - JOUR

T1 - Proteolytic Remodeling of Perineuronal Nets

T2 - Effects on Synaptic Plasticity and Neuronal Population Dynamics

AU - Lorenzo Bozzelli, P

AU - Alaiyed, Seham

AU - Kim, Eunyoung

AU - Villapol, Sonia

AU - Conant, Katherine

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus. It is thus apposed to sites at which PV neurons receive synaptic input. Emerging evidence suggests that changes in PNN integrity may affect glutamatergic input to PV interneurons, a population that is critical for the expression of synchronous neuronal population discharges that occur with gamma oscillations and sharp-wave ripples. The present review is focused on the composition of PNNs, posttranslation modulation of PNN components by sulfation and proteolysis, PNN alterations in disease, and potential effects of PNN remodeling on neuronal plasticity at the single-cell and population level.

AB - The perineuronal net (PNN) represents a lattice-like structure that is prominently expressed along the soma and proximal dendrites of parvalbumin- (PV-) positive interneurons in varied brain regions including the cortex and hippocampus. It is thus apposed to sites at which PV neurons receive synaptic input. Emerging evidence suggests that changes in PNN integrity may affect glutamatergic input to PV interneurons, a population that is critical for the expression of synchronous neuronal population discharges that occur with gamma oscillations and sharp-wave ripples. The present review is focused on the composition of PNNs, posttranslation modulation of PNN components by sulfation and proteolysis, PNN alterations in disease, and potential effects of PNN remodeling on neuronal plasticity at the single-cell and population level.

UR - http://www.scopus.com/inward/record.url?scp=85042496890&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85042496890&partnerID=8YFLogxK

U2 - 10.1155/2018/5735789

DO - 10.1155/2018/5735789

M3 - Review article

C2 - 29531525

SN - 2090-5904

VL - 2018

SP - 5735789

JO - Neural Plasticity

JF - Neural Plasticity

M1 - 5735789

ER -

Proteolytic Remodeling of Perineuronal Nets: Effects on Synaptic Plasticity and Neuronal Population Dynamics

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this