Proteins and cells on PEG immobilized silicon surfaces

Miqin Zhang, Tejal Desai, Mauro Ferrari

Research output: Contribution to journalArticle

350 Scopus citations

Abstract

Silicon surfaces were modified by covalent attachment of a self-assembled (SA) polyethylene glycol (PEG) film. Adsorption of albumin, fibrinogen, and IgG to PEG immobilized silicon surfaces was studied by ellipsometry to evaluate the non-fouling and non-immunogenic properties of the surfaces. The adhesion and proliferation of human fibroblast and Hela cells onto the modified surfaces were investigated to examine their tissue biocompatibility. Coated PEG chains showed the effective depression of both plasma protein adsorption and cell attachment to the modified surfaces. The mechanisms accounting for the reduction of protein adsorption and cell adhesion on modified surfaces were discussed.

Original languageEnglish (US)
Pages (from-to)953-960
Number of pages8
JournalBiomaterials
Volume19
Issue number10
DOIs
StatePublished - May 1 1998
Externally publishedYes

Keywords

  • Cellular interaction
  • Ellipsometry
  • PEG immobilization
  • Protein adsorption
  • Silicon

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Biomedical Engineering

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