Protein-directed synthesis of Bi2S3 nanoparticles as an efficient contrast agent for visualizing the gastrointestinal tract

Yan Zu, Yuan Yong, Xiao Zhang, Jie Yu, Xinghua Dong, Wenyan Yin, Liang Yan, Feng Zhao, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Non-invasive imaging modalities such as computed tomography are often used for diagnosis and assessment of gastrointestinal (GI) disease status over the long-term. The physiology of the GI tract can be assessed with contrast agents. Here, we present common protein (bovine serum albumin, BSA) stabilized bismuth sulfide nanoparticles with robust X-ray attenuation. Under the optimal conditions, this agent can outline the anatomy of the mouse GI tract on 3D computed tomography imaging, with the real-time and non-invasive visualization of nanoparticle distribution and the GI tract. Moreover, the investigation on long-term toxicity and biodistribution of these nanoparticles after oral administration indicate their overall safety. This is a promising agent for GI visualization and disease diagnosis.

Original languageEnglish (US)
Pages (from-to)17505-17513
Number of pages9
JournalRSC Advances
Volume7
Issue number28
DOIs
StatePublished - 2017

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

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