Protective role of heme oxygenase-1 in oxidative stress-induced neuronal injury

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141 Scopus citations

Abstract

Heme oxygenase-1 (HO-1) is a stress protein induced in response to a variety of oxidative challenges. After treatment of the hybrid septal cells SN 56 with β-amyloid peptide (β-AP1-40) or hydrogen peroxide (H2O2), we detected high levels of reactive oxygen species, accompanied by a significant elevation in HO-1 expression. Levels of HO-1 increased and then decreased following cell loss. Pretreatment of SN 56 cells with HO-1 antisense oligonucleotides dramatically decreased the immunoreactivity of HO- 1 and significantly enhanced the cytotoxicity of β-AP1-40 and H2O2. In contrast, pretreatment with hemin, an HO-1 inducer, increased the expression of HO-1 and decreased the β-AP1-40- and H2O2-induced cytotoxicity. These findings support the importance of HO-1 in protecting neurons against oxidative stress-induced injury.

Original languageEnglish (US)
Pages (from-to)652-658
Number of pages7
JournalJournal of Neuroscience Research
Volume56
Issue number6
DOIs
StatePublished - Jun 15 1999

Keywords

  • β-Amyloid
  • Alzheimer's disease
  • Antioxidant
  • Hydrogen peroxide

ASJC Scopus subject areas

  • Neuroscience(all)

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