Protective microglia and their regulation in Parkinson’s disease

Weidong Le, Junjiao Wu, Yu Tang

Research output: Contribution to journalReview article

51 Scopus citations

Abstract

Microglia-mediated neuroinflammation is a hallmark of Parkinson’s disease (PD). In the brains of patients with PD, microglia have both neurotoxic and neuroprotective effects, depending on their activation state. In this review, we focus on recent research demonstrating the neuroprotective role of microglia in PD. Accumulating evidence indicates that the protective mechanisms of microglia may result from their regulation of transrepression pathways via nuclear receptors, anti-inflammatory responses, neuron-microglia crosstalk, histone modification, and microRNA regulation. All of these mechanisms work together to suppress the production of neurotoxic inflammatory components. However, during the progression of PD, the detrimental effects of inflammation overpower the protective actions of microglia. Therefore, an in-depth exploration of the mechanisms underlying microglial neuroprotection, and a means of promoting the transformation of microglia to the protective phenotype, are urgently needed for the treatment of PD.

Original languageEnglish (US)
Article number89
JournalFrontiers in Molecular Neuroscience
Volume9
Issue numberSEP2016
DOIs
StatePublished - Sep 21 2016

Keywords

  • Alternative activation
  • Anti-inflammation
  • Histone modification
  • MicroRNA
  • Neuroinflammation
  • Parkinson’s disease
  • Transrepression pathway

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience

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