@article{313443a719204abc895d86df7e37fe24,
title = "Protecting vision in patients with diabetes with ultra-widefield imaging: A review of current literature",
abstract = "Ultra-widefield fundus imaging (UWFI) is a relatively new technology capable of capturing 200° images of the retina. Since vision changes can be irreversible in diabetic retinopathy (DR), recognition of prognostic biomarkers in the peripheral retina may prove invaluable toward optimizing the management and reducing the societal burden of this blinding disease. Following a bibliographic review using Pubmed, OVID Medline, Embase, and the Cochrane Library, the current review systematically examined 13 studies that compared UWFI to conventional screening techniques such as seven standard field (7SF) Early Treatment In Diabetic Retinopathy Study (ETDRS) and non-mydriatic multifield fundus photography (NMFP), as well as their scientific level of evidence. Overall, UWFI had good agreement with 7SF ETDRS and NMFP, and moderate agreement with dilated fundus examination. Seven additional studies were examined that considered the significance of peripheral lesions found on UWFI. These studies demonstrated that UWFI captured additional DR pathology in the peripheral retina that may not be evident if evaluation is limited to the posterior pole and may be relevant to patient outcomes. Future directions include but are not limited to the potential of UWFI to track the progression of DR with treatment.",
author = "Singh, {Rishi P.} and Jessica Hsueh and Han, {Michael M.} and Kuriyan, {Ajay E.} and Conti, {Felipe F.} and Nathan Steinle and Weng, {Christina Y.} and Wong, {Robert W.} and Martinez, {Jose A.} and Wykoff, {Charles C.}",
note = "Funding Information: {\textcopyright} 2019 Singh, Hsueh, Han, et al.; licensee SLACK Incorporated. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (https://creativecommons.org/ licenses/by/4.0). This license allows users to copy and distribute, to remix, transform, and build upon the article, for any purpose, even commercially, provided the author is attributed and is not represented as endorsing the use made of the work. Originally submitted November 16, 2018. Revision received January 28, 2019. Accepted for publication March 25, 2019. Dr. Singh has received personal fees from Optos and Zeiss during the conduct of the study, as well as grants and personal fees from Regeneron, Novartis/Alcon, and Genentech and personal fees from Bausch + Lomb outside the submitted work. Dr. Kuriyan has received personal fees from Allergan, Alimera Sciences, and Regeneron, and grants from Genentech, Second Sight, and Bayer outside the submitted work. Dr. Weng has received personal fees from Allergan and Alimera Sciences outside the submitted work. Dr. Wykoff has received grants from Adverum Biotechnologies, Aerpio Therapeutics, Alcon Laboratories, Aldeyra Therapeutics, Allegro, Apellis Pharmaceutical, Astellas Pharma, Aura Biosciences, Boehringer Ingelheim, Chiltern International, Heidelberg Engineering, Iconic Therapeutics, inc Research, Johns Hopkins University, NEI, OHR Pharmaceuticals, Ophthotech Corp, Regenxbio, SciFluor Life Sciences, Taiwan Liposome Company and Tyrogenex; personal fees from Alimera Sciences, Alnylam Pharmaceuticals, Bayer, CORCEPT, DORC International, Evolve Medical Education, k2c Medical Communications, Kodiak Sciences, Notal Vision, ONL Pharmaceuticals, and PRIME Educations; and grants and personal fees from Clearside Biomedical, EyePoint (formerly pSivida), Genentech, Novartis, Regeneron Pharmaceuticals, and Santen outside the submitted work. The remaining authors report no relevant financial disclosures. Dr. Singh did not participate in the editorial review of this manuscript. Address correspondence to Rishi P. Singh, MD, 9500 Euclid Avenue, Desk i32, Cleveland, OH 44195; email: SINGHR@ccf.org. doi: 10.3928/23258160-20191009-07 Publisher Copyright: {\textcopyright} 2019 Singh, Hsueh, Han, et al.; Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",
year = "2019",
doi = "10.3928/23258160-20191009-07",
language = "English (US)",
volume = "50",
pages = "639--648",
journal = "Ophthalmic surgery, lasers & imaging retina",
issn = "2325-8160",
publisher = "Slack Incorporated",
number = "10",
}