Prostatic carcinogenesis evoked by cellular interaction

L. W.K. Chung; S. M. Chang; C. Bell; H. Zhau; J. Y. Ro; A. C. Von Eschenbach

doi:10.1289/ehp.887723

Prostatic carcinogenesis evoked by cellular interaction

L. W.K. Chung, S. M. Chang, C. Bell, H. Zhau, J. Y. Ro, A. C. Von Eschenbach

Academic Institute

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

Original language	English (US)
Pages (from-to)	23-28
Number of pages	6
Journal	Environmental health perspectives
Volume	77
DOIs	https://doi.org/10.1289/ehp.887723
State	Published - 1988

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Health, Toxicology and Mutagenesis

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abstract = "Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.",

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AU - Chung, L. W.K.

AU - Chang, S. M.

AU - Bell, C.

AU - Zhau, H.

AU - Ro, J. Y.

AU - Von Eschenbach, A. C.

PY - 1988

Y1 - 1988

N2 - Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

AB - Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

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UR - https://www.scopus.com/inward/citedby.url?scp=0023925117&partnerID=8YFLogxK

U2 - 10.1289/ehp.887723

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SN - 0091-6765

VL - 77

SP - 23

EP - 28

JO - Environmental health perspectives

JF - Environmental health perspectives

ER -

Prostatic carcinogenesis evoked by cellular interaction

Abstract

ASJC Scopus subject areas

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