Prostatic carcinogenesis evoked by cellular interaction

L. W.K. Chung, S. M. Chang, C. Bell, H. Zhau, J. Y. Ro, A. C. Von Eschenbach

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Inoculation of tumorigenic prostatic stroma and nontumorigenic prostatic epithelia into the subcutaneous space of syngeneic rats induced the development of carcinosarcoma. The induced tumors, which were composed of a mixture of adenocarcinoma and fibrosarcoma, were androgen responsive. This model offers a novel mechanism for prostatic carcinogenesis in which prostatic fibroblasts determine epithelial growth, androgen responsiveness, and tumorigenicity. Our results emphasize the potential importance of an epigenetic pathway in prostatic carcinogenesis.

Original languageEnglish (US)
Pages (from-to)23-28
Number of pages6
JournalEnvironmental health perspectives
Volume77
DOIs
StatePublished - 1988

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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