TY - CHAP
T1 - Prostate Cancer Energetics and Biosynthesis
AU - Lin, Chenchu
AU - Salzillo, Travis C.
AU - Bader, David A.
AU - Wilkenfeld, Sandi R.
AU - Awad, Dominik
AU - Pulliam, Thomas L.
AU - Dutta, Prasanta
AU - Pudakalakatti, Shivanand
AU - Titus, Mark
AU - McGuire, Sean E.
AU - Bhattacharya, Pratip K.
AU - Frigo, Daniel
N1 - Publisher Copyright:
© Springer Nature Switzerland AG 2019.
PY - 2019
Y1 - 2019
N2 - Cancers must alter their metabolism to satisfy the increased demand for energy and to produce building blocks that are required to create a rapidly growing tumor. Further, for cancer cells to thrive, they must also adapt to an often changing tumor microenvironment, which can present new metabolic challenges (ex. hypoxia) that are unfavorable for most other cells. As such, altered metabolism is now considered an emerging hallmark of cancer. Like many other malignancies, the metabolism of prostate cancer is considerably different compared to matched benign tissue. However, prostate cancers exhibit distinct metabolic characteristics that set them apart from many other tumor types. In this chapter, we will describe the known alterations in prostate cancer metabolism that occur during initial tumorigenesis and throughout disease progression. In addition, we will highlight upstream regulators that control these metabolic changes. Finally, we will discuss how this new knowledge is being leveraged to improve patient care through the development of novel biomarkers and metabolically targeted therapies.
AB - Cancers must alter their metabolism to satisfy the increased demand for energy and to produce building blocks that are required to create a rapidly growing tumor. Further, for cancer cells to thrive, they must also adapt to an often changing tumor microenvironment, which can present new metabolic challenges (ex. hypoxia) that are unfavorable for most other cells. As such, altered metabolism is now considered an emerging hallmark of cancer. Like many other malignancies, the metabolism of prostate cancer is considerably different compared to matched benign tissue. However, prostate cancers exhibit distinct metabolic characteristics that set them apart from many other tumor types. In this chapter, we will describe the known alterations in prostate cancer metabolism that occur during initial tumorigenesis and throughout disease progression. In addition, we will highlight upstream regulators that control these metabolic changes. Finally, we will discuss how this new knowledge is being leveraged to improve patient care through the development of novel biomarkers and metabolically targeted therapies.
KW - AR
KW - Imaging
KW - Metabolism
KW - Prostate cancer
UR - http://www.scopus.com/inward/record.url?scp=85077480345&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85077480345&partnerID=8YFLogxK
U2 - 10.1007/978-3-030-32656-2_10
DO - 10.1007/978-3-030-32656-2_10
M3 - Chapter
C2 - 31900911
AN - SCOPUS:85077480345
T3 - Advances in Experimental Medicine and Biology
SP - 185
EP - 237
BT - Advances in Experimental Medicine and Biology
PB - Springer
ER -