Prostate Cancer Energetics and Biosynthesis

Chenchu Lin, Travis C. Salzillo, David A. Bader, Sandi R. Wilkenfeld, Dominik Awad, Thomas L. Pulliam, Prasanta Dutta, Shivanand Pudakalakatti, Mark Titus, Sean E. McGuire, Pratip K. Bhattacharya, Daniel Frigo

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations

Abstract

Cancers must alter their metabolism to satisfy the increased demand for energy and to produce building blocks that are required to create a rapidly growing tumor. Further, for cancer cells to thrive, they must also adapt to an often changing tumor microenvironment, which can present new metabolic challenges (ex. hypoxia) that are unfavorable for most other cells. As such, altered metabolism is now considered an emerging hallmark of cancer. Like many other malignancies, the metabolism of prostate cancer is considerably different compared to matched benign tissue. However, prostate cancers exhibit distinct metabolic characteristics that set them apart from many other tumor types. In this chapter, we will describe the known alterations in prostate cancer metabolism that occur during initial tumorigenesis and throughout disease progression. In addition, we will highlight upstream regulators that control these metabolic changes. Finally, we will discuss how this new knowledge is being leveraged to improve patient care through the development of novel biomarkers and metabolically targeted therapies.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer
Pages185-237
Number of pages53
DOIs
StatePublished - 2019

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1210
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • AR
  • Imaging
  • Metabolism
  • Prostate cancer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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