Prospective comparative trial of moxalactam versus amplicillin or chloramphenicol for treatment of haemophilus influenzae type b meningitis in children

Paul S. Lietman, Sheldon Kaplan, Edward Mason, Sally K. Mason, Francis I. Catlin, Rita T. Lee, Mary Murphy, Ralph D. Feigin

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

In a prospective, randomized study, moxalactam in 44 children was compared with amplicillin or chloramphenicol in 47 children for the treatment of Haemophilus influenzae type b meningitis. Both groups were comparable in terms of clinical and laboratory findings at admission. The hospital course, neurologic sequelae including deafness, and number of deaths were the same for both groups. The incidence of adverse reactions also was the same except that diarrhea and thrombocytosis occurred significantly (P≤0.04) more frequently in children given moxalactam. Moxalactam was equivalent to ampicillin or chloramphenicol in the treatment of H. influenzae type b meningitis in children.

Original languageEnglish (US)
Pages (from-to)447-453
Number of pages7
JournalThe Journal of Pediatrics
Volume104
Issue number3
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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