Prospective assessment of postoperative complications and associated costs following Inguinal Lymph Node Dissection (ILND) in Melanoma patients

Sharon B. Chang, Robert L. Askew, Yan Xing, Storm Weaver, Jeffrey E. Gershenwald, Jeffrey E. Lee, Richard Royal, Anthony Lucci, Merrick I. Ross, Janice N. Cormier

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

Background: We prospectively assessed the incidence, risk factors, and costs associated with wound complications and lymphedema in melanoma patients undergoing inguinal lymph node dissection (ILND). Materials and Methods: A total of 53 melanoma patients were accrued to 2 trials (June 2005 to July 2008) that included prospective evaluations of postoperative complications; 30-day wound complications included infection, seroma, and/or dehiscence. There were 20 patients who underwent limb volume measurement and completed a 19-item lymphedema symptom assessment questionnaire preoperatively and 3 months postoperatively. A multivariate analysis was performed to evaluate potential risk factors for complications. A microcosting analysis was also performed to evaluate the direct costs associated with wound complications. Results: The 30-day wound complications were noted in 77.4% of patients. A BMI > k for wound complications (odds ratio [OR] = 11.4, 95% confidence interval [95%CI] 1.6-78.5, P = .01), while advanced nodal disease approached significance (OR = 9.0, 95%CI: 0.79-103.1, P = .08). Other risk factors, including diabetes, smoking, and the addition of a deep pelvic (iliac/obturator) dissection to ILND, were not significant. Of 20 patients, 9 (45%) developed limb volume change (LVC) > 5% at 3 months, with associated mean symptom scores of 6.1 versus 4.6 for those without LVC. Costs for patients with wound complications were significantly higher than for those without wound complications. Conclusions: Postoperative wound complications and early onset lymphedema occur frequently following ILND for melanoma. Obesity is an adverse risk factor for 30-day wound complications that can significantly increase postoperative costs, as is likely the case for advanced disease. Risk reduction practices and novel treatment approaches are needed to reduce postoperative morbidity.

Original languageEnglish (US)
Pages (from-to)2764-2772
Number of pages9
JournalAnnals of Surgical Oncology
Volume17
Issue number10
DOIs
StatePublished - Oct 2010

ASJC Scopus subject areas

  • Surgery
  • Oncology

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