Propofol-induced dyskinesias in Parkinson's disease

Joachim K. Krauss, Edward W. Akeyson, Patrick Giam, Joseph Jankovic

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Spontaneous involuntary movements have been reported with the use of propofol, a parenteral anesthetic, in patients who had no prior history of movement disorders [1-4]. These movements were described as dystonic, choreoathetoid, or myoclonic. In patients with Parkinson's disease, propofol may temporarily suppress tremor [5]. We describe two patients with Parkinson's disease who underwent a stereotactic pallidotomy while off levodopa medication. In both patients, temporary sedation with propofol induced dyskinesias, which occurred in the same distribution and were phenomenologically similar to the levodopa-induced dyskinesias that these patients experienced. Possible antiparkinsonian and dyskinesia-inducing mechanisms of propofol are discussed.
Original languageEnglish (US)
Pages (from-to)420-422
Number of pages3
JournalAnesthesia and Analgesia
Volume83
Issue number2
DOIs
StatePublished - 1996

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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