TY - JOUR
T1 - Propofol-induced dyskinesias in Parkinson's disease
AU - Krauss, Joachim K.
AU - Akeyson, Edward W.
AU - Giam, Patrick
AU - Jankovic, Joseph
PY - 1996
Y1 - 1996
N2 - Spontaneous involuntary movements have been reported with the use of propofol, a parenteral anesthetic, in patients who had no prior history of movement disorders [1-4]. These movements were described as dystonic, choreoathetoid, or myoclonic. In patients with Parkinson's disease, propofol may temporarily suppress tremor [5]. We describe two patients with Parkinson's disease who underwent a stereotactic pallidotomy while off levodopa medication. In both patients, temporary sedation with propofol induced dyskinesias, which occurred in the same distribution and were phenomenologically similar to the levodopa-induced dyskinesias that these patients experienced. Possible antiparkinsonian and dyskinesia-inducing mechanisms of propofol are discussed.
AB - Spontaneous involuntary movements have been reported with the use of propofol, a parenteral anesthetic, in patients who had no prior history of movement disorders [1-4]. These movements were described as dystonic, choreoathetoid, or myoclonic. In patients with Parkinson's disease, propofol may temporarily suppress tremor [5]. We describe two patients with Parkinson's disease who underwent a stereotactic pallidotomy while off levodopa medication. In both patients, temporary sedation with propofol induced dyskinesias, which occurred in the same distribution and were phenomenologically similar to the levodopa-induced dyskinesias that these patients experienced. Possible antiparkinsonian and dyskinesia-inducing mechanisms of propofol are discussed.
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U2 - 10.1097/00000539-199608000-00037
DO - 10.1097/00000539-199608000-00037
M3 - Article
C2 - 8694329
AN - SCOPUS:0030035299
SN - 0003-2999
VL - 83
SP - 420
EP - 422
JO - Anesthesia and Analgesia
JF - Anesthesia and Analgesia
IS - 2
ER -