Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling

Huan Liu, Zhiming Wang, Jin He, Zongwei Li, Jerry Y. Gao, Rui Liu, Pei Lin, Jing Yang

Research output: Contribution to journalArticlepeer-review

Abstract

Osteolytic destruction is a hallmark of multiple myeloma and impairs myeloma patients’ quality of life. However, the molecular mechanism underlying the pathogenesis of myeloma-associated bone disease remains unclear. In this study, we demonstrate the role of myeloma cell-expressed integrin α6 in bone. Integrin α6 binds to laminin 8 and epidermal growth factor receptor on mesenchymal stem cells (MSCs) to form a trimer complex and upregulates the secretion of osteolytic cytokines from both myeloma cells and MSCs, leading to enhanced bone resorption and reduced bone formation. Thus, this study elucidates an important mechanism for myeloma-induced bone lesions and implicates that targeting integrin α6 may be a viable approach for bone healing in myeloma patients.

Original languageEnglish (US)
Article number692190
JournalFrontiers in Oncology
Volume11
DOIs
StatePublished - Jun 3 2021

Keywords

  • EGFR
  • bone lesion
  • integrin α6
  • laminin
  • multiple myeloma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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