Promise and pitfalls in animal-based asthma research: Building a better mousetrap

David B. Corry; Charles G. Irvin

doi:10.1385/IR:35:3:279

Promise and pitfalls in animal-based asthma research: Building a better mousetrap

David B. Corry, Charles G. Irvin

Research output: Contribution to journal › Review article › peer-review

34 Scopus citations

Abstract

Asthma is one of the leading chronic diseases in the world today. An essential component of the asthma research endeavor is the animal-based experimental disease system, which provides knowledge that is not attainable through study of patients alone. Animal research is especially valuable for elucidating pathophysiology, drug testing, and as an adjunct for interpreting the results of human clinical trials. However, controversies surrounding animal systems data and at the interface between animal and human studies raise questions regarding the true utility of experimental asthma research. We consider here the considerable promise and important limitations of animal-based systems and their prospects for the future study asthma.

Original language	English (US)
Pages (from-to)	279-294
Number of pages	16
Journal	Immunologic Research
Volume	35
Issue number	3
DOIs	https://doi.org/10.1385/IR:35:3:279
State	Published - Jul 2006

Keywords

Airway hyperresponsiveness
Animal model
Asthma
TH cell

ASJC Scopus subject areas

Immunology

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10.1385/IR:35:3:279

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title = "Promise and pitfalls in animal-based asthma research: Building a better mousetrap",

abstract = "Asthma is one of the leading chronic diseases in the world today. An essential component of the asthma research endeavor is the animal-based experimental disease system, which provides knowledge that is not attainable through study of patients alone. Animal research is especially valuable for elucidating pathophysiology, drug testing, and as an adjunct for interpreting the results of human clinical trials. However, controversies surrounding animal systems data and at the interface between animal and human studies raise questions regarding the true utility of experimental asthma research. We consider here the considerable promise and important limitations of animal-based systems and their prospects for the future study asthma.",

keywords = "Airway hyperresponsiveness, Animal model, Asthma, TH cell",

author = "Corry, {David B.} and Irvin, {Charles G.}",

note = "Funding Information: We thank H. Boushey and F. Kheradmand for helpful commentary. DBC is supported by grants HL6985, HL7543, and AI057696 from the United States National Institutes of Health and by the Sander Program for Asthma Research.",

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AB - Asthma is one of the leading chronic diseases in the world today. An essential component of the asthma research endeavor is the animal-based experimental disease system, which provides knowledge that is not attainable through study of patients alone. Animal research is especially valuable for elucidating pathophysiology, drug testing, and as an adjunct for interpreting the results of human clinical trials. However, controversies surrounding animal systems data and at the interface between animal and human studies raise questions regarding the true utility of experimental asthma research. We consider here the considerable promise and important limitations of animal-based systems and their prospects for the future study asthma.

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Promise and pitfalls in animal-based asthma research: Building a better mousetrap

Abstract

Keywords

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