Promise and pitfalls in animal-based asthma research: Building a better mousetrap

David B. Corry, Charles G. Irvin

Research output: Contribution to journalReview article

27 Scopus citations

Abstract

Asthma is one of the leading chronic diseases in the world today. An essential component of the asthma research endeavor is the animal-based experimental disease system, which provides knowledge that is not attainable through study of patients alone. Animal research is especially valuable for elucidating pathophysiology, drug testing, and as an adjunct for interpreting the results of human clinical trials. However, controversies surrounding animal systems data and at the interface between animal and human studies raise questions regarding the true utility of experimental asthma research. We consider here the considerable promise and important limitations of animal-based systems and their prospects for the future study asthma.

Original languageEnglish (US)
Pages (from-to)279-294
Number of pages16
JournalImmunologic Research
Volume35
Issue number3
DOIs
StatePublished - Jul 2006

Keywords

  • Airway hyperresponsiveness
  • Animal model
  • Asthma
  • TH cell

ASJC Scopus subject areas

  • Immunology

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