Progressive retinal nonperfusion in ischemic central retinal vein occlusion

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background: Serial wide-field fluorescein angiography was performed on eyes with preproliferative (ischemic) central retinal vein occlusion to evaluate retinal perfusion.

Method: Serial wide-field fluorescein angiography was performed on 12 preproliferative central retinal vein occlusion eyes in the 3-year Rubeosis Anti-VEGF (RAVE) trial using the Staurenghi lens (Ocular Staurenghi 230SLO Retina Lens) with a scanning laser ophthalmoscope (Heidelberg HRA Spectralis). "Disk area" was defined anatomically for each eye.

Results: Mean total field of gradable retina was 290 disk areas (range, 178-452). All eyes demonstrated extensive areas of retinal nonperfusion; at baseline, mean area of retinal perfusion was 106 disk areas (range, 37-129), correlating with a mean of 46.5% perfused retinal area (range, 19.1-56.4%). The area of retinal nonperfusion increased in all eyes with a mean loss of approximately 8.1% of perfused retinal area per year (range, 4.3-12.4%), which corresponded to a mean 15-disk areas (range, 12-35) of retina evolving from perfused to nonperfused annually. The extent of baseline and final nonperfusion was not significantly different between eyes that developed neovascularization and eyes that did not.

Conclusion: In this population of severe central retinal vein occlusion eyes, profound retinal nonperfusion was observed with wide-field fluorescein angiography at baseline and the extent of nonperfusion progressed while undergoing anti-vascular endothelial growth factor therapy.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalRetina
Volume35
Issue number1
DOIs
StatePublished - Jan 1 2015

Keywords

  • anti-VEGF
  • capillary dropout
  • central retinal vein occlusion
  • fluorescein angiography
  • ischemia
  • Ischemic Index
  • nonperfusion
  • perfusion
  • preproliferative
  • quantification
  • ranibizumab
  • RAVE
  • wide-field

ASJC Scopus subject areas

  • Ophthalmology

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