Progress of engineered antibody-targeted molecular imaging for solid tumors (review)

Hong Zhao, Kemi Cui, Andrea Muschenborn, Stephen T.C. Wong

Research output: Contribution to journalReview article

15 Scopus citations

Abstract

Engineered antibodies, with their high specificity and affinity for their target antigens, as well as their reduced size and multivalent design, can be tailored to carry radionuclide magnetic, luciferase or fluorescent probes for specific attachment to tissue cells, extracellularly or intracellularly, for PET, SPECT, MRI, optical and ultrasonic imaging. The antigen-specific imaging agents of engineered antibodies have deep tissue penetration, high tissue retention and fast blood clearance, which are desirable properties for the rapid imaging of tumors with high specificity and resolution in pre-clinical or clinical imaging studies.

Original languageEnglish (US)
Pages (from-to)131-134
Number of pages4
JournalMolecular Medicine Reports
Volume1
Issue number1
DOIs
StatePublished - 2008

Keywords

  • Engineered antibody
  • Molecular imaging
  • Solid tumor

ASJC Scopus subject areas

  • Biochemistry
  • Cancer Research
  • Genetics
  • Molecular Biology
  • Molecular Medicine
  • Oncology

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