Prognostic value of CT-derived left atrial and left ventricular measures in patients with acute chest pain

Richard A.P. Takx, Rozemarijn Vliegenthart, U. Joseph Schoepf, John W. Nance, Fabian Bamberg, Joseph A. Abro, Christine M. Carr, Sheldon E. Litwin, Paul Apfaltrer

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Purpose To determine which left atrial (LA) and left ventricular (LV) parameters are associated with future major adverse cardiac event (MACE) and whether these measurements have independent prognostic value beyond risk factors and computed tomography (CT)-derived coronary artery disease measures. Materials and methods This retrospective analysis was performed under an IRB waiver and in HIPAA compliance. Subjects underwent coronary CT angiography (CCTA) using a dual-source CT system for acute chest pain evaluation. LV mass, LV ejection fraction (EF), LV end-systolic volume (ESV) and LV end-diastolic volume (EDV), LA ESV and LA diameter, septal wall thickness and cardiac chamber diameters were measured. MACE was defined as cardiac death, non-fatal myocardial infarction, unstable angina, or late revascularization. The association between cardiac CT measures and the occurrence of MACE was quantified using Cox proportional hazard analysis. Results 225 subjects (age, 56.2 ± 11.2; 140 males) were analyzed, of whom 42 (18.7%) experienced a MACE during a median follow-up of 13 months. LA diameter (HR:1.07, 95%CI:1.01–1.13 per mm) and LV mass (HR:1.05, 95%CI:1.00–1.10 per g) remained significant prognostic factor of MACE after controlling for Framingham risk score. LA diameter and LV mass were also found to have prognostic value independent of each other. The other morphologic and functional cardiac measures were no significant prognostic factors for MACE. Conclusion CT-derived LA diameter and LV mass are associated with future MACE in patients undergoing evaluation for chest pain, and portend independent prognostic value beyond traditional risk factors, coronary calcium score, and obstructive coronary artery disease.

Original languageEnglish (US)
Pages (from-to)163-168
Number of pages6
JournalEuropean Journal of Radiology
Volume86
DOIs
StatePublished - Jan 1 2017

Keywords

  • Cardiovascular events
  • Computed tomography
  • Left atrial size
  • Left ventricular function

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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